Nemeth-Coslett R, Griffiths R R
Drug Alcohol Depend. 1985 May;15(1-2):1-13. doi: 10.1016/0376-8716(85)90024-9.
As part of a continuing series of studies to investigate the variables controlling various topographical aspects of cigarette smoking, the present study examined the extent to which cigarette rod length influenced smoking. Cigarette smoking was examined under conditions in which subjects smoked cigarettes they could not see. Both puff volume and puff duration varied as a direct function of rod length, although they were not highly correlated. Peak flow rate was not affected by rod length. Other results suggest that visual stimulus control and satiation did not affect puff volume. Comparison of puffing whole cigarettes versus short cigarette rods suggests that puff volume, but not puff duration, may be decreased in response to increased pharmacological delivery as a result of particulate build-up during smoking of a whole cigarette. Carbon monoxide (CO) exposure was substantially greater after puffing full length cigarette rods than after short cigarette rods. Comparison of these human CO data with CO delivery from syringe-simulated puffing of full length and short cigarette rods indicates that knowledge of puff volume and duration during human smoking is insufficient for accurately predicting biological (CO) exposure.
作为一系列持续研究的一部分，旨在探究控制吸烟各个地形学方面的变量，本研究考察了烟支长度对吸烟影响的程度。在受试者看不见所吸香烟的条件下对吸烟情况进行了检查。尽管吸量和吸持续时间的相关性不高，但它们均随烟支长度的直接变化而变化。峰值流速不受烟支长度的影响。其他结果表明，视觉刺激控制和饱腹感对吸量没有影响。吸整支香烟与吸短烟支的比较表明，由于吸整支烟时颗粒堆积导致药物递送增加，吸量可能会减少，但吸持续时间不会。吸全长烟支后一氧化碳（CO）暴露量比吸短烟支后大幅增加。将这些人体CO数据与通过注射器模拟吸全长和短烟支的CO递送情况进行比较表明，了解人体吸烟时的吸量和持续时间不足以准确预测生物（CO）暴露情况。
