Liljenström H, von Heijne G, Blomberg C, Johansson J
Eur Biophys J. 1985;12(2):115-9. doi: 10.1007/BF00260434.
With the aid of a kinetic model, we have investigated how the adaptation between the various components of the tRNA cycle and the codon frequencies affects the rate of protein synthesis. Depending on the relative amounts of total tRNA, synthetase and ribosomes, the optimal correlations vary between a situation where all tRNA species are either present in equal amounts or are present in amounts proportional to the square-root of the corresponding codon frequencies, and a situation where the amounts of the different tRNA species present are linearly proportional to the codon frequencies.
借助动力学模型，我们研究了tRNA循环各组分与密码子频率之间的适应性如何影响蛋白质合成速率。根据总tRNA、合成酶和核糖体的相对量，最佳相关性在以下两种情况之间变化：一种情况是所有tRNA种类以等量存在或以与相应密码子频率的平方根成比例的量存在；另一种情况是存在的不同tRNA种类的量与密码子频率成线性比例。
