Cerdàn S, Parrilla R, Santoro J, Rico M
FEBS Lett. 1985 Jul 22;187(1):167-72. doi: 10.1016/0014-5793(85)81235-7.
A previously unassigned group of prominent multiplets of the 360 MHz 1H NMR spectrum of acid stable metabolite extracts from rat brain is shown to arise from free myo-inositol. This conclusion is derived from a systematic analysis of the high-resolution 1H NMR spectra of brain acid extracts, in which appropriate conditions and optimal proton signals have been selected for the quantitative analysis of up to 15 metabolites. Developmental variations in the cerebral content of myo-inositol could be readily detected using this approach, which provides a novel alternative to study myo-inositol metabolism under physiological or pathological conditions.
大鼠脑酸性稳定代谢物提取物360 MHz 1H NMR谱中一组先前未被归属的显著多重峰被证明源自游离的肌醇。这一结论源于对脑酸性提取物高分辨率1H NMR谱的系统分析，其中已选择合适条件和最佳质子信号用于多达15种代谢物的定量分析。使用这种方法可以很容易地检测到脑中肌醇含量的发育变化，它为研究生理或病理条件下的肌醇代谢提供了一种新的替代方法。
