Liu Lu, Tian Xiaowei, Guo Yilin, Yu Yanyan, Wang Yamei, Wang Wenjing, Meng Jun, Li Guifang, Sun Xiaojuan
Department of Occupational Diseases, Weifang People's Hospital, Weifang, Shandong, China.
Department of Neurosurgery, Dongping Xian People's Hospital, Taian, Shandong, China.
Front Med (Lausanne). 2025 Mar 20;12:1479730. doi: 10.3389/fmed.2025.1479730. eCollection 2025.
Numerous studies have demonstrated that interleukin (IL) plays an essential role in the development of chronic inflammatory diseases, especially in pneumoconiosis. The association between various IL gene polymorphisms and pneumoconiosis susceptibility has been investigated extensively, but the results remain controversial. A literature search was conducted using PubMed, EMBASE, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI), and Wanfang database to obtain relevant studies before 22 January 2025. Subsequently, odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the strength of correlations. A sensitivity analysis was performed to evaluate the robustness and reliability of the included studies. Overall, there was a significant association between IL-1RA +2018 and IL-6 -634 with the risk of pneumoconiosis. The IL-1RA +2018 variant was positively associated with an increased risk of pneumoconiosis among both Asians and Caucasians. In contrast, the IL-6 -634 genotype was associated with a lower risk of pneumoconiosis among Asians. Additionally, the IL-1RA +2018 genotype was significantly linked to a predisposition to coal workers' pneumoconiosis (CWP) and silicosis. The IL-6 -634 mutant significantly decreased silicosis and CWP risk. Additional large-scale replication studies are needed to elucidate the precise role of various IL SNPs in the etiology of pneumoconiosis.
众多研究表明，白细胞介素（IL）在慢性炎症性疾病的发展中起着至关重要的作用，尤其是在尘肺病中。各种IL基因多态性与尘肺病易感性之间的关联已得到广泛研究，但结果仍存在争议。使用PubMed、EMBASE、Web of Science、Cochrane图书馆、中国知网（CNKI）和万方数据库进行文献检索，以获取2025年1月22日前的相关研究。随后，使用具有95%置信区间（CI）的比值比（OR）来评估相关性强度。进行敏感性分析以评估纳入研究的稳健性和可靠性。总体而言，IL-1RA +2018和IL-6 -634与尘肺病风险之间存在显著关联。IL-1RA +2018变异体在亚洲人和白种人中均与尘肺病风险增加呈正相关。相比之下，IL-6 -634基因型在亚洲人中与较低的尘肺病风险相关。此外，IL-1RA +2018基因型与煤工尘肺（CWP）和矽肺的易感性显著相关。IL-6 -634突变体显著降低了矽肺和CWP风险。需要更多大规模的重复研究来阐明各种IL单核苷酸多态性在尘肺病病因学中的精确作用。
