Corfield A P, Cooper M J, Williamson R C
Gut. 1985 Jul;26(7):724-9. doi: 10.1136/gut.26.7.724.
Between 1968 and 1979 650 patients in the Bristol clinical area suffered 737 attacks of acute pancreatitis. Sex distribution was approximately equal and mean age was 60 years. Comparison with the previous decade shows an increase in mean annual incidence of first attacks from 53.8 to 73.0 cases per million population. Case mortality was unchanged at 20%. In no less than 35% of fatal cases the diagnosis was first made at necropsy. Gall stones were detected in 50% of first attacks, predominantly in women. The proportion of alcoholics (8% overall) increased three-fold during the period of the study. In 23% of cases no aetiological cause was identified. Eighty patients suffered 99 recurrent attacks of acute pancreatitis, with a mortality rate (12%) that was not significantly lower than that of the first attack. Neglected gall stones accounted for 51% of these subsequent attacks.
1968年至1979年间，布里斯托尔临床区域的650名患者发生了737次急性胰腺炎发作。性别分布大致相等，平均年龄为60岁。与前十年相比，首次发作的年平均发病率从每百万人口53.8例增加到73.0例。病例死亡率保持在20%不变。在不少于35%的致命病例中，诊断是在尸检时首次做出的。在50%的首次发作病例中检测到胆结石，主要见于女性。在研究期间，酗酒者的比例（总体为8%）增加了两倍。在23%的病例中未发现病因。80名患者发生了99次急性胰腺炎复发，死亡率（12%）并不显著低于首次发作。被忽视的胆结石占这些后续发作的51%。
