Di Lieto Maria Chiara, Matteucci Elisa, Martinelli Alice, Beani Elena, Menici Valentina, Martini Giada, Barzacchi Veronica, Dubbini Nevio, Sgandurra Giuseppina
Department of Developmental Neuroscience, IRCCS Fondazione Stella Maris, Calambrone, Pisa, Italy.
Department of Developmental Neuroscience, IRCCS Fondazione Stella Maris, Calambrone, Pisa, Italy; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Res Dev Disabil. 2025 Jun;161:105004. doi: 10.1016/j.ridd.2025.105004. Epub 2025 Apr 4.
Cerebral Palsy (CP) may impact the quality of life (QOL) and social.participation in different life situations and the discussion concerning the predictive.factors related is still open. The aim of the present study is to investigate the QOL in.Italian children with CP by a parent-reported questionnaire, evaluating the predictive.role of social participation and of motor and cognitive levels on the QOL dimensions.
Seventy-one children with CP (31 males and 40 females) and with a mean age 8.9 years (SD 2.5 years) participated in this study and the Cerebral Palsy Quality of Life Questionnaire for Children (CP-QOL-Child) questionnaire was fulfilled by their parents. Type of CP, The Participation and Environment Measure for Children and Youth questionnaire (PEM-CY), functional motor level (described with GMFCS and MACS) and cognitive profile (Wechsler scales assessment) were collected.
Significant differences within CP-QOL domains were found (X2(6) = 176.38,p < .001). The age and the level of environmental helpfulness in social participation impacted significantly the majority of CP-QOL domains (p < .001). The MACS and Verbal cognitive levels significantly influence CP-QOL domains, in terms of Feeling about functioning and Family health as Social wellbeing respectively(p < .001). The GMFCS level does not directly predict QOL but significantly impacts the environmental helpfulness in social participation (p < .001).
Beside the known role of motor impairment in determining QOL, the verbal cognitive level and the parent-perception of environmental supports in social context,also represent significant co-predictive factors of QOL. Important implications in terms of multidimensional social and health care of children with CP may be proposed.
脑性瘫痪（CP）可能会影响生活质量（QOL）以及在不同生活情境中的社会参与，且有关相关预测因素的讨论仍在进行。本研究的目的是通过家长报告问卷调查意大利CP患儿的生活质量，评估社会参与以及运动和认知水平对生活质量维度的预测作用。
71名CP患儿（31名男性和40名女性）参与了本研究，平均年龄8.9岁（标准差2.5岁），其家长填写了儿童脑性瘫痪生活质量问卷（CP-QOL-Child）。收集了CP类型、儿童和青少年参与与环境测量问卷（PEM-CY）、功能性运动水平（用GMFCS和MACS描述）以及认知概况（韦氏量表评估）。
在CP-QOL各领域发现了显著差异（X2(6) = 176.38，p <.001）。社会参与中的年龄和环境支持程度对大多数CP-QOL领域有显著影响（p <.001）。MACS和语言认知水平分别在功能感受和家庭健康作为社会幸福感方面对CP-QOL领域有显著影响（p <.001）。GMFCS水平不能直接预测生活质量，但对社会参与中的环境支持有显著影响（p <.001）。
除运动障碍在决定生活质量方面的已知作用外，语言认知水平以及家长对社会背景中环境支持的感知，也是生活质量的重要共同预测因素。可以提出对CP患儿多维社会和医疗保健具有重要意义的建议。
