Marzorati Chiara, Voskanyan Viktorya, Sala Diana, Grasso Roberto, Borgogni Federico, Pietrobon Ricardo, van der Heide Iris, Engelaar Merel, Bos Nanne, Caraceni Augusto, Couspel Norbert, Ferrer Montse, Groenvold Mogens, Kaasa Stein, Lombardo Claudio, Sirven Aude, Vachon Hugo, Gilbert Alexandra, Brunelli Cinzia, Apolone Giovanni, Pravettoni Gabriella
Applied Research Division for Cognitive and Psychological Science, IEO, European Institute of Oncology IRCCS, Milan, Italy.
Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.
Health Qual Life Outcomes. 2025 Apr 5;23(1):31. doi: 10.1186/s12955-025-02357-z.
Cancer treatment greatly impacts physical and psychological functioning of cancer patients, negatively affecting their quality of life (QoL). This Umbrella Review (UR) aims to systematically summarize psychological and social factors positively or negatively associated with QoL in cancer patients undergoing treatment.
Four scientific databases (PubMed, Embase, Scopus, and PsycInfo) were searched to identify systematic reviews between 2012 and 2023 analyzing the relationship between QoL and psychosocial factors in cancer patients in treatment. The UR was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and Joanna Briggs Institute (JBI) review guidelines. The methodological quality of the included studies was evaluated using Assessment of Multiple Systematic Reviews 2 (AMSTAR2).
Eighteen systematic reviews were included. The major psychological factors influencing QoL are depression, coping strategies, anxiety, and distress. Results also demonstrate the significant impact of social factors on QoL: perceived social support has a positive influence on QoL of cancer patients, while lowered social support, impaired social functioning, interactions, and role limitations worsen their QoL and overall well-being.
This UR provides a comprehensive overview of the psychosocial factors impacting QoL of cancer patients and serves as a prominent base for developing questionnaires and policies aimed at measuring QoL in cancer patients undergoing treatment. Moreover, the findings of the study can guide future research or the development of personalized clinical interventions aimed at improving QoL for this cancer population group.
癌症治疗对癌症患者的身体和心理功能有很大影响，会对他们的生活质量（QoL）产生负面影响。本伞状综述（UR）旨在系统总结与接受治疗的癌症患者生活质量呈正相关或负相关的心理和社会因素。
检索了四个科学数据库（PubMed、Embase、Scopus和PsycInfo），以确定2012年至2023年间分析癌症患者治疗期间生活质量与心理社会因素之间关系的系统综述。本伞状综述按照系统评价和Meta分析的首选报告项目（PRISMA）以及乔安娜·布里格斯研究所（JBI）的综述指南进行。使用多重系统评价评估2（AMSTAR2）对纳入研究的方法学质量进行评估。
纳入了18项系统综述。影响生活质量的主要心理因素是抑郁、应对策略、焦虑和痛苦。结果还表明社会因素对生活质量有重大影响：感知到的社会支持对癌症患者的生活质量有积极影响，而社会支持降低、社会功能受损、互动和角色限制会使他们的生活质量和整体幸福感恶化。
本伞状综述全面概述了影响癌症患者生活质量的心理社会因素，并为开发旨在测量接受治疗的癌症患者生活质量的问卷和政策提供了重要基础。此外，该研究结果可指导未来的研究或开发旨在改善这一癌症人群生活质量的个性化临床干预措施。
