Zmbova B, Konstantinovska-Djokić D, Tadzer I
Int J Appl Radiat Isot. 1985 May;36(5):389-94. doi: 10.1016/0020-708x(85)90280-7.
A procedure is described for synthesis of p-butyl IDA and for identification of the product by i.r. and NMR spectroscopy and by chemical analysis. A method for preparing this compound by "instant" technique and for its labelling with 99mTc is also given, as well as a procedure for control of the chemical and biological properties of the radiopharmaceutical. Radiochemical study shows a high labelling yield of 95%. Investigation of the biodistribution proves that this preparation is a good hepatobiliary reagent, suitable for use in investigation of the liver functions and for quantitative visualization of the hepatobiliary system.
本文描述了对碘代二乙胺（IDA）合成对丁基衍生物的方法，以及通过红外光谱、核磁共振光谱和化学分析对产物进行鉴定的过程。还给出了通过“即时”技术制备该化合物及其用99mTc标记的方法，以及控制放射性药物化学和生物学性质的程序。放射化学研究表明标记产率高达95%。生物分布研究证明该制剂是一种良好的肝胆试剂，适用于肝功能检查和肝胆系统的定量显像。
