Qiu Wenxin, Han Ying, Huang Jingru, Chen Danjing, Fang Jiangwang, Chang Huajing, Peng Xian-E
Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, People's Republic of China.
Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, People's Republic of China.
J Clin Hypertens (Greenwich). 2025 Apr;27(4):e70042. doi: 10.1111/jch.70042.
Oxidative stress plays an important role in the development of hypertension (HTN). A population-based cross-sectional study was conducted in Fujian province of China. The construction of FoodL-OBS relied on diet and lifestyle components, which included four food and six lifestyle factors. Multivariable-adjusted logistic regression was performed to investigate the association between FoodL-OBS and the risk of HTN. A subgroup analysis was also conducted. Restricted cubic spline (RCS) regression was used to elucidate the dose-response relationship between FoodL-OBS and the risk of HTN. A total of 9578 participants were included, 3271 of whom suffered from HTN. The results of multivariable logistic regression analysis showed that the HTN risk decreased by 14% for each FoodL-OBS unit added [OR: 0.86 (0.84, 0.88), p < 0.01]. Compared with participants with the lowest levels of Food-L-OBS, those with the highest quartile were less likely to have HTN [0.43 (0.37, 0.50)]. Further stratified analysis showed that Food-L-OBS was negatively associated with the risk of HTN, which was statistically significant in participants in subgroups of ≤60 years, female, and no-dyslipidemia. The results of RCS showed a linear negative correlation between Food-L-OBS and HTN in men, but not in women. In conclusion, FoodL-OBS was negatively associated with HTN, and a healthy lifestyle and antioxidant-rich diet may be useful for preventing HTN.
氧化应激在高血压（HTN）的发生发展中起重要作用。在中国福建省进行了一项基于人群的横断面研究。FoodL-OBS的构建依赖于饮食和生活方式因素，其中包括四种食物和六种生活方式因素。采用多变量调整的逻辑回归分析来研究FoodL-OBS与HTN风险之间的关联。还进行了亚组分析。使用限制立方样条（RCS）回归来阐明FoodL-OBS与HTN风险之间的剂量反应关系。共纳入9578名参与者，其中3271人患有HTN。多变量逻辑回归分析结果显示，每增加一个FoodL-OBS单位，HTN风险降低14%[比值比：0.86（0.84，0.88），p<0.01]。与Food-L-OBS水平最低的参与者相比，处于最高四分位数的参与者患HTN的可能性较小[0.43（0.37，0.50）]。进一步的分层分析表明，Food-L-OBS与HTN风险呈负相关，在年龄≤60岁、女性和无血脂异常的亚组参与者中具有统计学意义。RCS结果显示，Food-L-OBS与男性的HTN呈线性负相关，但与女性无关。总之，FoodL-OBS与HTN呈负相关，健康的生活方式和富含抗氧化剂的饮食可能有助于预防HTN。
