Mukasa David Christopher, Ononge Sam, Namagembe Imelda, Byamugisha Josaphat, Sekikubo Musa, Muyingo Mark, Nakasujja Noeline
Department of Obstetrics and Gynaecology, Makerere University, Kampala, Uganda.
University hospital, Makerere University, Kampala, Uganda.
Afr Health Sci. 2024 Dec;24(4):214-223. doi: 10.4314/ahs.v24i4.28.
Depression affects approximately 364 million people globally. Prenatal depression affects between 26.3% and 32.9% of mothers in Africa. Opportunities for prenatal screening are missed. The gold standard diagnostic, the Diagnostic and Statistical Manual of Mental Disorders-Fifth edition (DSM-5) criteria for Major Depressive Disorder (MDD) has higher technical requirement. There is inadequate information on locally adapted and validated user-friendly screening tools in Uganda.
To Adapt and validate the Luganda Edinburgh Postnatal Depression Scale (EPDS-L) for screening prenatal depression at Kawempe National Referral hospital (KNRH).
Cross-sectional study in KNRH using International Society for Pharmacoeconomics and Outcomes Research guidelines for adaptation and quantitative approaches for the validation. Consecutive sampling until the desired sample of 100, all participants responded to both EPDS-L and DSM-5 criteria for MDD. Reliability demonstrated using Cronbach's alpha coefficient, while validity was demonstrated by sensitivity, specificity, Negative Predictive Value (NPV), Positive Predictive Value (PPV) and Area-Under-the-curve (AUC).
EPDS-L had Cronbach's-Alpha of 0.8515. At cut-off of 13, sensitivity was 62.86%, specificity-100%, PPV-100% and NPV-83.3%. AUC was 0.99. Performance was better at cut-off of 10, with sensitivity-97.14% and specificity-98.46%.
The EPDS-L is reliable at cut-off of 13 but performs even better at cut-off of 10.
抑郁症在全球约影响3.64亿人。产前抑郁症在非洲影响26.3%至32.9%的母亲。产前筛查机会被错过。黄金标准诊断，即《精神疾病诊断与统计手册》第五版（DSM-5）中重度抑郁症（MDD）的标准技术要求较高。在乌干达，关于本地适用且经过验证的用户友好型筛查工具的信息不足。
在卡韦姆佩国家转诊医院（KNRH）对卢干达版爱丁堡产后抑郁量表（EPDS-L）进行改编和验证，以筛查产前抑郁症。
在KNRH进行横断面研究，采用国际药物经济学与结果研究学会的改编指南和验证的定量方法。连续抽样直至达到100的目标样本，所有参与者均对EPDS-L和MDD的DSM-5标准做出回应。使用克朗巴哈α系数证明信度，通过敏感性、特异性、阴性预测值（NPV）、阳性预测值（PPV）和曲线下面积（AUC）证明效度。
EPDS-L的克朗巴哈α系数为0.8515。截断值为13时，敏感性为62.86%，特异性为100%，PPV为100%，NPV为83.3%。AUC为0.99。截断值为10时表现更好，敏感性为97.14%，特异性为98.46%。
EPDS-L在截断值为13时可靠，但在截断值为10时表现更佳。
