Franz K B, Rüddel H, Todd G L, Dorheim T A, Buell J C, Eliot R S
J Am Coll Nutr. 1985;4(2):187-94. doi: 10.1080/07315724.1985.10720075.
In a single case study of a moderately trained, healthy man, physiologic changes during a marathon are reported. Blood was drawn prior to the race, at 1 hour and 2 hours into the race, at the end of the race, and after 1 hour of recovery. By 1 hour into the race, norepinephrine, epinephrine, and dopamine had increased nearly nine-fold, two-fold and five-fold, respectively. After 1 hour of recovery, epinephrine had returned to the pre-race value but norepinephrine and dopamine were still elevated. Cortisol increased gradually and was more than doubled by the end of the race. It was still elevated after 1 hour of recovery. White blood cells gradually increased, reaching their maximum value at the end of the race; a four-to-five-fold increase. Thromboxane B2, which had an inverse relationship to serum magnesium, was below the pre-race value for the first 2 hours but increased nine-fold by the end of the race. Serum magnesium increased from 1.44 meq/l to 1.68 meq/l at 2 hours into the marathon, dropped to 1.07 meq/l by the end of the race, and returned to its pre-race value by 1 hour of recovery. The decrease in serum magnesium at the end of the race may be associated with increased plasma free fatty acid levels.
在一项针对一名训练有素的健康男性的单病例研究中，报告了马拉松比赛期间的生理变化。在比赛前、比赛进行1小时和2小时时、比赛结束时以及恢复1小时后采集血液样本。到比赛进行1小时时，去甲肾上腺素、肾上腺素和多巴胺分别增加了近9倍、2倍和5倍。恢复1小时后，肾上腺素已恢复到赛前水平，但去甲肾上腺素和多巴胺仍处于升高状态。皮质醇逐渐增加，到比赛结束时增加了一倍多。恢复1小时后仍处于升高状态。白细胞逐渐增加，在比赛结束时达到最大值，增加了4至5倍。与血清镁呈负相关的血栓素B2在比赛的前2小时低于赛前水平，但在比赛结束时增加了9倍。马拉松比赛进行2小时时，血清镁从1.44毫当量/升升至1.68毫当量/升，到比赛结束时降至1.07毫当量/升，并在恢复1小时后恢复到赛前水平。比赛结束时血清镁的降低可能与血浆游离脂肪酸水平升高有关。
