Department of Chemical Safety, Nofer Institute of Occupational Medicine, 91-348 Lodz, Poland.
Int J Environ Res Public Health. 2022 May 5;19(9):5608. doi: 10.3390/ijerph19095608.
Endometriosis is a disease characterized by the presence of the uterine endometrium outside of its normal location. As the etiology of endometriosis is not well known and hormonal imbalance is central to disease pathogenesis, the potential contribution of exposure to endocrine-disrupting chemicals (EDCs) has been hypothesized in endometriosis. A systematic search of the literature was carried out to identify relevant studies using: PubMed, Scopus, Elsevier, Springer; EBSCO, and Web of Science. A total of 22 studies were considered. Most of the studies reviewed in this paper showed an association between exposure to BPA and phthalates and endometriosis. In the case of phthalate exposure, the reviewed studies found an association between the concentration of at least one phthalate metabolite and endometriosis. Only one study was performed to assess the exposure to parabens and a significant relationship with endometriosis was found. Additionally, only one study assessed the relationship of non-persistent pesticide exposure with endometriosis, observing a significant association between endometriosis and the urinary concentration of diazinon, chlorpyrifos, and chlorpyrifos-methyl. Studies struggled to provide a conclusion on the effect of exposure to benzophenones on endometriosis. Despite the numerous limitations of the results, the reviewed studies suggest that exposure to non-persistent endocrine disruptors, especially bisphenol A and phthalates may affect endometriosis. The results of the studies on exposure to parabens, benzophenones, and non-persistent insecticides are inconclusive.
子宫内膜异位症是一种疾病，其特征是子宫内 膜出现在其正常位置之外。由于子宫内膜异位症的病因尚不清楚，而激素失衡是疾病发病机制的核心，因此人们假设暴露于内分泌干扰化学物质（EDCs）可能与子宫内膜异位症有关。通过使用 PubMed、Scopus、Elsevier、Springer；EBSCO 和 Web of Science 进行了系统的文献搜索，以确定相关研究。共考虑了 22 项研究。本文综述的大多数研究表明，暴露于 BPA 和邻苯二甲酸酯与子宫内膜异位症之间存在关联。就邻苯二甲酸酯暴露而言，综述研究发现至少一种邻苯二甲酸酯代谢物的浓度与子宫内膜异位症之间存在关联。只有一项研究评估了对防腐剂的暴露情况，发现其与子宫内膜异位症之间存在显著关系。此外，只有一项研究评估了非持久性农药暴露与子宫内膜异位症的关系，观察到子宫内膜异位症与二嗪农、毒死蜱和毒死蜱-甲基在尿中的浓度之间存在显著关联。研究难以就接触苯并二恶英对子宫内膜异位症的影响得出结论。尽管结果存在许多局限性，但综述研究表明，接触非持久性内分泌干扰物，尤其是双酚 A 和邻苯二甲酸酯可能会影响子宫内膜异位症。关于接触对羟基苯甲酸酯、苯并二恶英和非持久性杀虫剂的研究结果尚无定论。
