Talebi Sepide, Shab-Bidar Sakineh, Askari Gholamreza, Mohammadi Hamed, Moini Ashraf, Djafarian Kurosh
Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
J Res Med Sci. 2025 Jan 30;30:5. doi: 10.4103/jrms.jrms_280_24. eCollection 2025.
The objective of this study was to compare the effects of early time-restricted eating (eTRE) and eTRE plus probiotic supplementation to daily caloric restriction (DCR) alone in terms of biomarkers of oxidative stress (OS), antioxidant capacity, inflammation, and blood pressure (BP) in obese women with polycystic ovary syndrome (PCOS).
The research was conducted as a randomized, parallel, placebo-controlled clinical trial with an 8-week follow-up period. Participants were randomly assigned to one of three groups: 14:10 eTRE with probiotic supplementation ( = 30), 14:10 eTRE with placebo supplementation ( = 30), or DCR with placebo supplementation ( = 30). At the beginning and 8 weeks of the intervention, systolic blood pressure (SBP) and diastolic BP, inflammation, and OS parameters were evaluated.
A total of 90 participants (mean age, 30.49 years and mean weight, 81.45 kg) were enrolled in this trial. After 8-week intervention, we observed SBP significantly decreased in both the eTRE + probiotic group (-0.31 mmHg [95% confidence interval (CI): -0.55, -0.07]) and the eTRE + placebo group (-0.24 mmHg [95% CI: -0.43, 0.04]), with no significant differences observed between groups. Moreover, C-reactive protein (CRP) levels were significantly reduced in all groups ( < 0.005). Total antioxidant capacity (TAC) also showed notable improvement in both the eTRE + probiotic group ( = 0.012) and the DCR group ( = 0.032). However, there were no significant differences between the three groups regarding BP, OS, TAC, and CRP markers.
It was not found that eTRE alone or eTRE with probiotics intervention resulted in improving BP, inflammatory, OS, and antioxidant capacity biomarkers than a standard DCR diet among obese women with PCOS. The present study did not reveal significant improvements in BP, inflammatory markers, OS, or antioxidant capacity with either eTRE alone or eTRE combined with probiotics compared to a standard DCR among obese women diagnosed with PCOS.Trial Register no: IRCT20121110011421N5.
本研究的目的是比较早期限时进食（eTRE）和eTRE联合益生菌补充与单纯每日热量限制（DCR）对多囊卵巢综合征（PCOS）肥胖女性氧化应激（OS）、抗氧化能力、炎症和血压（BP）生物标志物的影响。
本研究为一项随机、平行、安慰剂对照的临床试验，随访期为8周。参与者被随机分配到三组中的一组：补充益生菌的14:10 eTRE组（n = 30）、补充安慰剂的14:10 eTRE组（n = 30）或补充安慰剂的DCR组（n = 30）。在干预开始时和第8周，评估收缩压（SBP）、舒张压、炎症和OS参数。
本试验共纳入90名参与者（平均年龄30.49岁，平均体重81.45 kg）。经过8周的干预，我们观察到eTRE + 益生菌组（-0.31 mmHg [95%置信区间（CI）：-0.55，-0.07]）和eTRE + 安慰剂组（-0.24 mmHg [95% CI：-0.43，0.04]）的SBP均显著降低，两组之间未观察到显著差异。此外，所有组的C反应蛋白（CRP）水平均显著降低（P < 0.005）。总抗氧化能力（TAC）在eTRE + 益生菌组（P = 0.012）和DCR组（P = 0.032）中也有显著改善。然而，三组在BP、OS、TAC和CRP标志物方面没有显著差异。
在PCOS肥胖女性中，未发现单独的eTRE或eTRE联合益生菌干预在改善BP、炎症、OS和抗氧化能力生物标志物方面比标准DCR饮食更有效。与标准DCR相比，本研究未发现单独的eTRE或eTRE联合益生菌在BP、炎症标志物、OS或抗氧化能力方面有显著改善。试验注册号：IRCT20121110011421N5。
