Liedtke Nina, Boeltzig Marius, Mecklenbrauck Falko, Siestrup Sophie, Schubotz Ricarda I
Department of Psychology, University of Münster, Fliednerstraße 21, 48149 Münster, Germany; Otto Creutzfeldt Center for Cognitive and Behavioral Neuroscience, University of Münster, Germany.
Neuroimage. 2025 May 1;311:121194. doi: 10.1016/j.neuroimage.2025.121194. Epub 2025 Apr 8.
Previous research has highlighted the critical role of prediction errors (PEs) in signaling the need to adapt memory representations in response to unexpected changes in the environment. Yet, the influence of PE type and strength on memory remains underexplored. In this study, participants encoded naturalistic dialogues prior to undergoing fMRI scanning. During the fMRI session, they listened to dialogues that had been modified in their surface or gist, to varying extents. As expected, our findings revealed robust activation in the inferior frontal gyrus for all PEs. Notably, gist modifications elicited additional activations within the episodic memory network, including the hippocampus. A post-fMRI recognition test demonstrated that surface modifications had no significant impact on memory. Conversely, weak gist changes impaired memory for the original content and hindered learning of the modification. These weak gist changes also triggered activation in the parahippocampal cortex. These results underscore the importance of both the type and strength of PEs in shaping brain activations and memory outcomes, highlighting their complex interplay in cognitive processes.
先前的研究强调了预测误差（PEs）在表明需要根据环境中的意外变化调整记忆表征方面的关键作用。然而，PE类型和强度对记忆的影响仍未得到充分探索。在本研究中，参与者在进行功能磁共振成像（fMRI）扫描之前对自然主义对话进行编码。在fMRI实验过程中，他们听取了在表面或主旨上有不同程度修改的对话。正如预期的那样，我们的研究结果显示，所有PEs均在额下回引发了强烈激活。值得注意的是，主旨修改在情景记忆网络（包括海马体）中引发了额外的激活。fMRI后的识别测试表明，表面修改对记忆没有显著影响。相反，微弱的主旨变化损害了对原始内容的记忆，并阻碍了对修改内容的学习。这些微弱的主旨变化还触发了海马旁皮质的激活。这些结果强调了PEs的类型和强度在塑造大脑激活和记忆结果方面的重要性，突出了它们在认知过程中的复杂相互作用。
