ABO血型与精神障碍之间的关系。
Relationship Between ABO Blood Groups and Mental Disorders.
作者信息
Ajdacic-Gross Vladeta, Buadze Ana, Wagner En-Young N, Müller Mario, Seifritz Erich, Ranjbar Setareh, Glaus Jennifer, Castelao Enrique, Strippoli Marie-Pierre F, Vandeleur Caroline L, Preisig Martin, von Känel Roland
机构信息
Department of Adult Psychiatry and Psychotherapy, Psychiatric University Clinic Zurich and University of Zurich, Zurich, Switzerland.
Department of Consultation-Liaison Psychiatry and Psychosomatic Medicine, University Hospital Zurich and University of Zurich, Zurich, Switzerland.
出版信息
J Blood Med. 2025 Jan 3;16:1-5. doi: 10.2147/JBM.S470340. eCollection 2025.
Previous research has unveiled an intriguing positive association between the AB blood group and mental disorders in general. In this study, we compared ABO blood groups with five major groups of mental disorders to attain a higher level of specificity. The analyses were conducted using data from the CoLaus|PsyCoLaus study (N=5111). They revealed that the AB blood group exhibited a positive association with both neurodevelopmental disorders (RR 2.29, CI 1.38-3.82) and substance use disorders (RR 2.25, CI 1.38-3.65) after adjusting for sex and childhood adversities. These associations could be replicated with respect to the familial aggregation of neurodevelopmental and substance use disorders. Large databases are needed to achieve more detailed results related to specific disorders.
先前的研究揭示了AB血型与一般精神障碍之间存在一种有趣的正相关关系。在本研究中，我们将ABO血型与五大类精神障碍进行比较，以获得更高的特异性水平。分析使用了来自CoLaus|PsyCoLaus研究的数据（N = 5111）。结果显示，在对性别和童年逆境进行调整后，AB血型与神经发育障碍（相对风险2.29，可信区间1.38 - 3.82）和物质使用障碍（相对风险2.25，可信区间1.38 - 3.65）均呈正相关。这些关联在神经发育障碍和物质使用障碍的家族聚集方面可以得到重复验证。需要大型数据库来获得与特定障碍相关的更详细结果。
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