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在莫桑比克基于人群的艾滋病毒影响评估(INSIDA 2021)中,艾滋病毒感染者未披露已知的艾滋病毒感染状况。

Non-disclosure of Known HIV Status among People Living with HIV in the Mozambique Population-Based HIV Impact Assessment (INSIDA 2021).

作者信息

McCabe K Carter, Augusto Angelo, Koole Olivier, McCracken Stephen D, Tiberi Orrin, Boothe Makini, Sathane Isabel, Honwana Nely, McOwen Jordan, Young Peter W

机构信息

Division of Global HIV & TB, U.S. Centers for Disease Control and Prevention (CDC), Maputo, Mozambique.

Instituto Nacional de Saúde (INS), Maputo, Mozambique.

出版信息

AIDS Behav. 2025 Apr 10. doi: 10.1007/s10461-025-04699-7.

Abstract

Non-disclosure of known HIV-positive status is a barrier to ending HIV as a global health threat as it leads to biased measurements of HIV-treatment coverage indicators and inaccurate estimates of epidemic progress, resulting in wasted resources. Identifying and understanding factors driving non-disclosure among people living with HIV is necessary for encouraging engagement with HIV services and improving treatment coverage, resource allocation, and monitoring of HIV programs in high HIV-burden areas. This analysis assessed factors associated with non-disclosure among survey respondents who had antiretrovirals (ARVs) detected in blood specimens. HIV-positive blood specimens (n = 2,038) from the 2021 Mozambique Population-based HIV Impact Assessment were tested for the presence of ARVs. Weighted prevalence estimates of non-disclosure and select covariates are reported and factors associated with non-disclosure modeled via multivariate logistic regression. Among 1,358 respondents with ARVs detected, 14.1% did not self-report their HIV-positive status during the interview. Adjusting for socio-demographic and clinical factors, non-disclosure was more likely among younger participants aged 15-24 years (adjusted odds ratio [aOR]: 2.15, 95% Confidence Interval [CI] 1.16-4.01) and among those without knowledge of their recent sexual partner's HIV-status (aOR: 2.67, 95%CI: 1.38-5.15). Participants with an unsuppressed viral load were over six times (aOR: 6.27, 95%CI: 2.76-14.23) more likely to not disclose. Improving disclosure rates is vital to obtaining accurate HIV-treatment estimates and assessing epidemic progress. Initiatives prioritizing pre- and post-test counseling, stressing treatment literacy, emphasizing undetectable = untransmittable (U = U) campaigns, and encouraging programs that promote social support may encourage disclosure among individuals living with HIV.

摘要

不披露已知的艾滋病毒阳性状态是消除艾滋病毒作为全球健康威胁的一个障碍,因为它导致对艾滋病毒治疗覆盖率指标的有偏差测量以及对疫情进展的不准确估计,从而造成资源浪费。识别和理解推动艾滋病毒感染者不披露信息的因素,对于鼓励他们参与艾滋病毒服务、提高治疗覆盖率、资源分配以及监测高艾滋病毒负担地区的艾滋病毒项目而言是必要的。本分析评估了在血液样本中检测到抗逆转录病毒药物(ARV)的调查对象中与不披露信息相关的因素。对来自2021年莫桑比克基于人群的艾滋病毒影响评估的艾滋病毒阳性血液样本(n = 2,038)进行了ARV检测。报告了不披露信息和选定协变量的加权患病率估计值,并通过多变量逻辑回归对与不披露信息相关的因素进行建模。在检测到ARV的1,358名调查对象中,14.1%在访谈期间未自我报告其艾滋病毒阳性状态。在调整了社会人口统计学和临床因素后,15至24岁的年轻参与者(调整后的优势比[aOR]:2.15,95%置信区间[CI] 1.16 - 4.01)以及那些不知道其近期性伴侣艾滋病毒状态的参与者(aOR:2.67,95%CI:1.38 - 5.15)更有可能不披露信息。病毒载量未得到抑制的参与者不披露信息的可能性高出六倍多(aOR:6.27,95%CI:2.76 - 14.23)。提高披露率对于获得准确的艾滋病毒治疗估计值和评估疫情进展至关重要。优先开展检测前和检测后咨询、强调治疗知识、强调“检测不到=不具传染性”(U=U)宣传活动以及鼓励促进社会支持的项目等举措,可能会鼓励艾滋病毒感染者披露信息。

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