Gershon H, Jerome J A, McElwain K F
J Pharm Sci. 1985 May;74(5):556-8. doi: 10.1002/jps.2600740513.
Twelve 3-n-alkyn-1-ols (C4-C12, C14, C16, and C18) were tested against Aspergillus oryzae, Aspergillus niger, Trichoderma viride, and Myrothecium verrucaria in Sabouraud dextrose agar at pH 5.6 and 7.0. Toxicity to Candida albicans, Candida tropicalis, Trichophyton mentagrophytes, and Mucor mucedo was determined in the same medium at pH 5.6 and 7.0 in the absence and presence of 10% beef serum. Fungitoxicity was strongly influenced by chain length, slightly by pH of the medium, and significantly but not strongly by the presence of beef serum. 3-n-Decyn-1-ol, 3-n-undecyn-1-ol, and 3-n-dodecyn-1-ol were the most active members of the series. Synergism toward C. albicans and C. tropicalis was observed between 3-n-undecyn-1-ol and ketoconazole, and a mixture of 3-n-undecyn-1-ol, 2-n-undecyn-1-ol, and ketoconazole in Sabouraud dextrose agar at pH 7.0 in the presence of 10% human serum.
在pH值为5.6和7.0的沙氏葡萄糖琼脂培养基中，对12种3 - n - 炔基 - 1 - 醇（碳链长度为C4 - C12、C14、C16和C18）进行了针对米曲霉、黑曲霉、绿色木霉和疣孢漆斑菌的测试。在pH值为5.6和7.0的相同培养基中，分别在不存在和存在10%牛血清的情况下，测定了其对白色念珠菌、热带念珠菌、须癣毛癣菌和匍枝根霉的毒性。杀真菌毒性受碳链长度的影响很大，受培养基pH值的影响较小，受牛血清存在的影响显著但不强烈。3 - n - 癸炔 - 1 - 醇、3 - n - 十一炔 - 1 - 醇和3 - n - 十二炔 - 1 - 醇是该系列中活性最强的成员。在pH值为7.0且存在10%人血清的沙氏葡萄糖琼脂培养基中，观察到3 - n - 十一炔 - 1 - 醇与酮康唑对白色念珠菌和热带念珠菌有协同作用，以及3 - n - 十一炔 - 1 - 醇、2 - n - 十一炔 - 1 - 醇和酮康唑的混合物也有协同作用。
