Gershon H, Shanks L
Can J Microbiol. 1976 Aug;22(8):1198-201. doi: 10.1139/m76-176.
Thirteen alpha, omega-alkanedicarboxylic acids (C2-C12, C14, and C16) and their dimethyl esters were tested against Aspergillus niger, Trichoderma viride, and Myrothecium verrucaria in Sabourauc dextrose agar at pH 4.0 AND 5.6. Toxicity to Canadida albicans, Trichophyton mentagrophytes, and Mucor mucedo was determined in the same medium at pH 5.6 and 7.0 in the absence and presence of 10% beef serum. The dicarboxylic acids possessed very poor to no antifungal activity against all six fungi. The fungitoxicity of the dimethyl esters to A. niger, T. viride, and M. verrucaria was C8 = C9 greater than C7 greater than C6 = C5 greater than C10 greater than C4 greater than C11 and to C. albicans, T. mentagrophytes, and M. mucedo C9 greater than C10 greater than C11 greater than C12 = C8 greater than C7 greater than C6 greater than C5 greater than C4 greater than C3. The fungitoxicity of the esters of fatty acids and alpha-omega-alkanedicarboxylic acids was influenced by chain length and not by the pH of the medium or the absence or presence of beef serum.
在pH值为4.0和5.6的沙氏葡萄糖琼脂培养基中，对13种α,ω - 链烷二羧酸（C2 - C12、C14和C16）及其二甲酯针对黑曲霉、绿色木霉和疣孢漆斑菌进行了测试。在pH值为5.6和7.0的相同培养基中，在不存在和存在10%牛血清的情况下，测定了它们对白色念珠菌、须癣毛癣菌和匐枝根霉的毒性。二羧酸对所有六种真菌的抗真菌活性极差或无活性。二甲酯对黑曲霉、绿色木霉和疣孢漆斑菌的杀真菌毒性为C8 = C9大于C7大于C6 = C5大于C10大于C4大于C11，对白色念珠菌、须癣毛癣菌和匐枝根霉的杀真菌毒性为C9大于C10大于C11大于C12 = C8大于C7大于C6大于C5大于C4大于C3。脂肪酸和α,ω - 链烷二羧酸酯的杀真菌毒性受链长影响，而不受培养基pH值或牛血清的存在与否影响。
