Gershon H, Rowe G E, Santore R C, Gilbertson J R, Langkamp H
J Pharm Sci. 1984 Dec;73(12):1840-2. doi: 10.1002/jps.2600731250.
Fourteen 2-n-alkynols (C3-C14, C16, and C18) were tested against Aspergillus oryzae, Aspergillus niger, Trichoderma viride, and Myrothecium verrucaria in Sabouraud dextrose agar at pH 5.6 and 7.0. Toxicity to Candida albicans, Candida tropicalis, Trichophyton mentagrophytes, and Mucor mucedo was determined in the same medium at pH 5.6 and 7.0 in the absence and presence of 10% beef serum. Fungitoxicity was strongly influenced by chain length, slightly by the pH of the medium, and significantly by the presence of beef serum. 2-n-Undecyn-1-ol was the most active member of the series, and there was marked synergism between it and ketoconazole.
在pH值为5.6和7.0的沙氏葡萄糖琼脂培养基中，对14种2-正炔醇（C3 - C14、C16和C18）进行了针对米曲霉、黑曲霉、绿色木霉和疣孢漆斑菌的测试。在pH值为5.6和7.0的相同培养基中，分别在不存在和存在10%牛血清的情况下，测定了它们对白色念珠菌、热带念珠菌、须癣毛癣菌和毛霉的毒性。杀真菌活性受链长影响很大，受培养基pH值影响较小，受牛血清的存在影响显著。2-正十一碳炔-1-醇是该系列中活性最强的成员，并且它与酮康唑之间存在明显的协同作用。
