取代硝基苯和苯胺的抗真菌活性。
Antifungal activity of substituted nitrobenzenes and anilines.
作者信息
Gershon H, McNeil M W, Parmegiani R, Godfrey P K
出版信息
Appl Microbiol. 1971 Sep;22(3):438-40. doi: 10.1128/am.22.3.438-440.1971.
Series of 1,3-dihalogeno-5-nitrobenzenes, 3- and 3,5-halogenoanilines, and 2,6-dihalogeno-4-nitroanilines were tested for fungitoxicity against Aspergillus niger, A. oryzae, Trichoderma viride, Myrothecium verrucaria, and Trichophyton mentagrophytes in shaken culture by using Sabouraud dextrose broth enriched with yeast extract as the test medium. 1,3-Dichloro-5-nitrobenzene, 1,3-dibromo-5-nitrobenzene, 3-iodoaniline, 3,5-dichloroaniline, and 3,5-dibromoaniline were found to possess sufficient activity, compared with 8-quinolinol, to warrant further study.
测试了一系列1,3 - 二卤代 - 5 - 硝基苯、3 - 和3,5 - 卤代苯胺以及2,6 - 二卤代 - 4 - 硝基苯胺对黑曲霉、米曲霉、绿色木霉、疣孢漆斑菌和须癣毛癣菌的真菌毒性，在振荡培养中使用添加酵母提取物的沙氏葡萄糖肉汤作为测试培养基。与8 - 羟基喹啉相比，发现1,3 - 二氯 - 5 - 硝基苯、1,3 - 二溴 - 5 - 硝基苯、3 - 碘苯胺、3,5 - 二氯苯胺和3,5 - 二溴苯胺具有足够的活性，值得进一步研究。
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