辛德毕斯病毒缺陷干扰RNA的信使核糖核酸活性
mRNA activity of a Sindbis virus defective-interfering RNA.
作者信息
Migliaccio G, Castagnola P, Leone A, Cerasuolo A, Bonatti S
出版信息
J Virol. 1985 Sep;55(3):877-80. doi: 10.1128/JVI.55.3.877-880.1985.
Abstract
We obtained Sindbis defective-interfering particles by nine and undiluted passages of standard virus on chicken embryo fibroblasts. These particles contain a deleted 20S RNA molecule which has mRNA activity, as shown by translation in cell-free systems in vitro. In infected cells, this mRNA activity appeared to be totally inhibited except at very late times postinfection.
摘要
我们通过标准病毒在鸡胚成纤维细胞上进行九次传代和未稀释传代获得了辛德毕斯缺陷干扰颗粒。这些颗粒含有一个缺失的20S RNA分子，该分子具有mRNA活性，如在无细胞体外系统中的翻译所示。在受感染的细胞中，这种mRNA活性似乎完全受到抑制，除非在感染后非常晚的时间。
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