Yong Gong Yi, Kamkaew Anyanee, Kue Chin Siang
School of Graduate Studies, Management and Science University, Shah Alam, Malaysia.
School of Chemistry, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima, Thailand.
Nanomedicine (Lond). 2025 May;20(9):967-983. doi: 10.1080/17435889.2025.2489342. Epub 2025 Apr 11.
Photothermal therapy (PTT) utilizes photothermal agents (PTAs) to generate heat at the local tumor site that leads to ablation upon photoirradiation at a specific wavelength of light. Currently, most of the available PTAs have weak tumor selectivity and depositing ability, which leads to poor therapeutic outcomes. PEGylation of PTAs improves therapeutic outcomes, prolongs systemic circulation time, enhances tumor accumulation, and reduces the risk of clearance by the immune system. This paper reviews the recent developments of PEGylated PTAs in photothermal cancer therapy from 2019 to 2023, highlighting their antitumour efficacy and immune response post-therapy with immune agents, current challenges and strategies. This review aims to foster knowledge dissemination on the application of nanomedicine in photothermal cancer therapy from an immunological perspective and to encourage the clinical translation of these nanomaterials.
光热疗法（PTT）利用光热剂（PTA）在局部肿瘤部位产生热量，在特定波长的光照射下导致肿瘤消融。目前，大多数可用的PTA具有较弱的肿瘤选择性和沉积能力，这导致治疗效果不佳。PTA的聚乙二醇化改善了治疗效果，延长了全身循环时间，增强了肿瘤积累，并降低了被免疫系统清除的风险。本文综述了2019年至2023年聚乙二醇化PTA在光热癌症治疗中的最新进展，重点介绍了它们的抗肿瘤疗效以及与免疫剂联合治疗后的免疫反应、当前面临的挑战和策略。这篇综述旨在从免疫学角度促进纳米医学在光热癌症治疗中应用的知识传播，并鼓励这些纳米材料的临床转化。
