Stockton A, Farhat G, McDougall Gordon J, Al-Dujaili E A S
Department of Dietetics, Nutrition and Biological Sciences, Queen Margaret University, Musselburgh, East Lothian EH21 6UU, UK.
Environmental and Biochemical Sciences Group, The James Hutton Institute, Dundee DD2 5DA, UK.
J Nutr Sci. 2017 Aug 9;6:e39. doi: 10.1017/jns.2017.36. eCollection 2017.
Pomegranate (), a polyphenol-rich fruit, has been suggested to reduce cardiovascular risk due to its antioxidant properties. Hypertension and obesity are the most preventable cardiovascular risk factors. Few studies on blood pressure and/or body-weight status have been conducted in human subjects. Previous investigations have tended to focus on pomegranate juice. The aim of the present study was to investigate the effect of pomegranate extract (PE) on blood pressure and anthropometric measures in adults with no symptomatic disease. A total of fifty-five participants enrolled in a randomised double-blinded placebo-controlled clinical trial where they were assigned to either PE capsules or placebo capsules for 8 weeks. Blood pressure, body weight, waist circumference, waist:hip ratio (WHR) and body composition (lean body mass, body fat) were measured at baseline, week 4 and week 8. Results showed a significant decrease in diastolic blood pressure after 8 weeks (by 2·79 (sd 5·32) mmHg; < 0·05), while the decrease in systolic blood pressure did not reach statistical significance (2·57 (sd 7·4) mmHg; > 0·05). Body fat percentage, lean body mass, waist circumference and WHR did not significantly differ between groups at the end of the intervention. Results suggest that PE may reduce blood pressure and possibly prevent hypertension in the normotensive population. Further large trials are required to elucidate this effect.
石榴是一种富含多酚的水果，因其抗氧化特性，被认为可以降低心血管疾病风险。高血压和肥胖是最可预防的心血管危险因素。针对人体受试者开展的关于血压和/或体重状况的研究较少。以往的研究往往集中在石榴汁上。本研究的目的是调查石榴提取物（PE）对无症状疾病成年人血压和人体测量指标的影响。共有55名参与者参加了一项随机双盲安慰剂对照临床试验，他们被分配服用PE胶囊或安慰剂胶囊，为期8周。在基线、第4周和第8周测量血压、体重、腰围、腰臀比（WHR）和身体成分（瘦体重、体脂）。结果显示，8周后舒张压显著下降（下降2.79（标准差5.32）mmHg；P<0.05），而收缩压下降未达到统计学显著性（下降2.57（标准差7.4）mmHg；P>0.05）。干预结束时，两组之间的体脂百分比、瘦体重、腰围和WHR没有显著差异。结果表明，PE可能会降低血压，并可能预防血压正常人群患高血压。需要进一步开展大型试验来阐明这种效果。
