Nejatian Hoseinpour Ali, Bassami Minoo, Ahmadizad Sajad, Donath Lars, Setayesh Shayan, Mirzaei Meraj, Mohammad Rahimi Gholam Rasul
Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Allameh Tabataba'I University, Tehran, Iran.
Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Allameh Tabataba'I University, Tehran, Iran; Research institutes of Sport Science and health, Allameh Tabataba'i University, Tehran, Iran.
Arch Gerontol Geriatr. 2025 Mar;130:105731. doi: 10.1016/j.archger.2024.105731. Epub 2024 Dec 25.
Older adults experience chronic inflammation, which is associated with health conditions such as sarcopenia, and resulting in reduced functional capacity. Resistance training (RT) is a beneficial intervention for improving health in the elderly.
This study aimed to investigate the effect of RT on inflammatory biomarkers, body composition, and functional capacity in healthy adults aged 60 years and over. Additionally, this study conducted a meta-regression to investigate the moderating effect of exercise variables on inflammatory markers.
Medline, PubMed, Web of Science, Cochrane Library, Embase, and Google Scholar were searched systematically until December 2023. Randomized controlled trials (RCTs) assessing the impact of RT on C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α), body weight, BMI, fat percentage, fat mass, lean mass, leg extension strength and six-minute walk test (6-MWT) were included. Effect size was estimated by using the mean difference (MD) with 95 % confidence interval (CI).
Nineteen RTCs involving 728 participants were included. The results revealed that CRP levels significantly decreased following RT programs (MD:0.74, p= 0.008), while TNF-α (MD: 0.1, p= 0.95) and IL-6 (MD:0.27, p= 0.12) did not show significant changes. Additionally, RT enhanced leg extension strength and 6-MWT performance.
RT effectively reduces CRP concentrations and enhances functional capacity in healthy older adults. However, it does not have a significant impact on TNF-α and IL-6 levels. Future researches are needed to make a clear conclusion and understand the mechanisms underlying the effects of RT in healthy older adults.
The original protocol was registered (CRD42023487573) in PROSPERO database.
老年人经历慢性炎症，这与肌肉减少症等健康状况相关，并导致功能能力下降。抗阻训练（RT）是改善老年人健康的有益干预措施。
本研究旨在调查抗阻训练对60岁及以上健康成年人炎症生物标志物、身体成分和功能能力的影响。此外，本研究进行了元回归分析，以调查运动变量对炎症标志物的调节作用。
系统检索了截至2023年12月的Medline、PubMed、科学网、考克兰图书馆、Embase和谷歌学术。纳入评估抗阻训练对C反应蛋白（CRP）、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）、体重、体重指数、脂肪百分比、脂肪量、瘦体重、伸腿力量和六分钟步行试验（6-MWT）影响的随机对照试验（RCT）。效应量采用均数差（MD）和95%置信区间（CI）进行估计。
纳入了19项涉及728名参与者的随机对照试验。结果显示，抗阻训练后CRP水平显著降低（MD：0.74，p = 0.008），而TNF-α（MD：0.1，p = 0.95）和IL-6（MD：0.27，p = 0.12）未显示出显著变化。此外，抗阻训练增强了伸腿力量和6-MWT表现。
抗阻训练可有效降低健康老年人的CRP浓度并增强功能能力。然而，它对TNF-α和IL-6水平没有显著影响。需要进一步的研究来得出明确结论，并了解抗阻训练对健康老年人影响的潜在机制。
原始方案已在PROSPERO数据库中注册（CRD42023487573）。
