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乳腺从单分散细胞的生长以及对7,12-二甲基苯并[a]蒽的敏感性。

Growth of mammary glands from monodispersed cells and susceptibility to 7,12-dimethylbenz[alpha]anthracene.

作者信息

Sinha D K

出版信息

Cancer Lett. 1981 Mar;12(1-2):111-19. doi: 10.1016/0304-3835(81)90046-x.

DOI:10.1016/0304-3835(81)90046-x
PMID:6791816
Abstract

Monodispersed mammary cells inoculated into the subscapular fat pad of isologous female rats developed into full-formed ductal mammary glands. The growth pattern of these outgrowths followed that of normal mammary gland, as indicated by labeling index (LI). Tumorigenesis in these outgrowths induced by 7,12-dimethylbenz[alpha]anthracene (DMBA) was in direct proportion to the level of LI. A similar correlation of tumorigenesis and LI was also observed in the mammary gland of virgin female rats. Our data show that application of this technique in the study of mammary cell physiology and carcinogenesis would be very useful.

摘要

接种到同基因雌性大鼠肩胛下脂肪垫中的单分散乳腺细胞发育成了完整的导管乳腺。如标记指数(LI)所示,这些外植体的生长模式与正常乳腺的生长模式一致。7,12-二甲基苯并[a]蒽(DMBA)诱导的这些外植体中的肿瘤发生与LI水平成正比。在未生育雌性大鼠的乳腺中也观察到了肿瘤发生与LI的类似相关性。我们的数据表明,将该技术应用于乳腺细胞生理学和致癌作用的研究将非常有用。

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Growth of mammary glands from monodispersed cells and susceptibility to 7,12-dimethylbenz[alpha]anthracene.乳腺从单分散细胞的生长以及对7,12-二甲基苯并[a]蒽的敏感性。
Cancer Lett. 1981 Mar;12(1-2):111-19. doi: 10.1016/0304-3835(81)90046-x.
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引用本文的文献

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Tumorigenesis of rat mammary epithelial cells by N-nitroso-N-methylurea in an in vitro system: characterization of the microtumors.N-亚硝基-N-甲基脲在体外系统中诱导大鼠乳腺上皮细胞发生肿瘤形成:微小肿瘤的特征
In Vitro Cell Dev Biol Anim. 1996 Apr;32(4):204-10. doi: 10.1007/BF02722947.
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In vitro carcinogenesis of mammary epithelial cells by N-nitroso-N-methylurea using a collagen gel matrix culture.使用胶原凝胶基质培养法,通过N-亚硝基-N-甲基脲诱导乳腺上皮细胞的体外致癌作用。
In Vitro Cell Dev Biol Anim. 1993 Oct;29A(10):789-94. doi: 10.1007/BF02634346.
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Hormones and mammary carcinogenesis in mice, rats, and humans: a unifying hypothesis.
小鼠、大鼠和人类中的激素与乳腺癌发生:一个统一假说。
Proc Natl Acad Sci U S A. 1995 Apr 25;92(9):3650-7. doi: 10.1073/pnas.92.9.3650.
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Role of serum and hormones during the growth and development of rat mammary tumor epithelial cells in collagen gel culture.血清和激素在大鼠乳腺肿瘤上皮细胞胶原凝胶培养生长发育过程中的作用
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