Zhong Xing, Chen Yichen, Sun Lianghong, Chen Hua, Qu Xiaobing, Hao Lipeng
School of Public Health, Fudan University, Shanghai, 200032, China.
Shanghai Pudong New Area Center for Disease Control and Prevention (Shanghai Pudong New Area Health Supervision Institute), Shanghai, 200136, China.
Sci Rep. 2025 Apr 13;15(1):12715. doi: 10.1038/s41598-025-96745-6.
Ischaemic heart disease (IHD) remains a major public health threat globally. The aim of this study was to evaluate the short-term burden of air pollution exposure on years of life lost (YLLs) from IHD in Pudong New Area, Shanghai. Data on air pollutants, meteorological factors, and daily IHD deaths were collected from 2013 to 2021. A distributed lag nonlinear model (DLNM) combined with linear (for YLLs) and quasi-Poisson (for mortality) regression models was applied to analyse the association between air pollution exposure and the IHD burden. A stratified analysis was conducted according to sex, age, education level, and residence registration. Each 10 µg/m³ increase in PM, SO, and NO exposure was associated with YLL increases of 0.40 (95% CI: -0.32, 1.11), 4.38 (95% CI: 0.83, 7.92), and 0.67 (95% CI: -0.71, 2.04) years, respectively, at lag0-3. The corresponding YLL increase due to PM exposure was 0.28 (95% CI: -0.24, 0.80) years at lag0-1. The impacts of air pollution exposure on YLLs and daily IHD deaths were greater for male and urban groups than for female and rural groups. Furthermore, the difference in SO exposure was statistically significant among sex-stratified groups. Air pollution exposure was positively associated with IHD-related YLL increases in Pudong New Area, Shanghai.
缺血性心脏病（IHD）仍然是全球主要的公共卫生威胁。本研究的目的是评估上海浦东新区空气污染暴露对因IHD导致的寿命损失年数（YLLs）的短期负担。收集了2013年至2021年的空气污染物、气象因素和IHD每日死亡数据。应用分布滞后非线性模型（DLNM）结合线性（用于YLLs）和准泊松（用于死亡率）回归模型来分析空气污染暴露与IHD负担之间的关联。根据性别、年龄、教育水平和户籍进行了分层分析。在滞后0 - 3时，PM、SO和NO暴露每增加10 µg/m³，YLLs分别增加0.40（95%CI：-0.32，1.11）、4.38（95%CI：0.83，7.92）和0.67（95%CI：-0.71，2.04）年。在滞后0 - 1时，由于PM暴露导致的相应YLL增加为0.28（95%CI：-0.24，0.80）年。空气污染暴露对YLLs和IHD每日死亡的影响在男性和城市组中比在女性和农村组中更大。此外，在按性别分层的组中，SO暴露的差异具有统计学意义。上海浦东新区的空气污染暴露与IHD相关的YLL增加呈正相关。
