Yerby M S, Sundsten J W, Larson E B, Wu S A, Sumi S M
Neurology. 1985 Sep;35(9):1316-20. doi: 10.1212/wnl.35.9.1316.
A new method of measuring cerebral atrophy using a ratio of brain parenchyma to ventricular and subarachnoid space is described. It uses digitized brain CT. This ratio was measured prospectively on 117 consecutive elderly patients referred for evaluation of cognitive dysfunction. Diagnosis was determined by preestablished criteria and confirmed by follow-up. Despite the improved accuracy and reproducibility of this method, its ability to differentiate persons with senile dementia of the Alzheimer's type (SDAT) from those suffering from pseudodementia was confounded by age, and was hence of limited utility. We conclude that even with sophisticated measures of cerebral atrophy, CT is unable to discriminate among common causes of cognitive dysfunction in the elderly.
描述了一种使用脑实质与脑室及蛛网膜下腔比例来测量脑萎缩的新方法。该方法使用数字化脑CT。对117例因认知功能障碍前来评估的连续老年患者进行了该比例的前瞻性测量。诊断根据预先确定的标准确定，并通过随访得到证实。尽管该方法的准确性和可重复性有所提高，但其区分阿尔茨海默型老年性痴呆（SDAT）患者与假性痴呆患者的能力受到年龄的干扰，因此效用有限。我们得出结论，即使采用复杂的脑萎缩测量方法，CT也无法区分老年人认知功能障碍的常见病因。
