Chen Xuan, Zhang Mengjie, Zhao Yang, Xue Qiaosheng, Xu Yingjun, Zuo Liping, Wang Zhijun, Tang Yingli, Cai Yufeng, Zheng Xiangde, Liu Cheng, Liu Si, Wang Chuanlin
Department of Emergency, Peking University First Hospital, Beijing, China.
Department of Emergency, Norinco General Hospital, Xi'an City, Shaanxi Province, China.
China CDC Wkly. 2025 Mar 28;7(13):441-448. doi: 10.46234/ccdcw2025.071.
WHAT IS ALREADY KNOWN ABOUT THIS TOPIC?: The incidence of tetanus in China remains significantly higher than in economically developed regions. Tetanus vaccination represents the most scientifically validated and efficient approach to tetanus prevention. However, vaccine hesitancy presents substantial barriers to the widespread implementation of non-neonatal tetanus vaccination programs across China.
WHAT IS ADDED BY THIS REPORT?: This study constitutes the first comprehensive investigation of tetanus vaccine hesitancy in China, documenting its current prevalence and underlying determinants. Findings reveal that limited knowledge about tetanus vaccines, complacency regarding tetanus risk, advanced age, and other factors significantly contribute to vaccination hesitancy. The research demonstrates that medical institutions and healthcare providers offering evidence-based information about tetanus prevention may substantially enhance vaccination uptake.
WHAT ARE THE IMPLICATIONS FOR PUBLIC HEALTH PRACTICE?: By elucidating the specific reasons for tetanus vaccine refusal among trauma patients, this study provides critical insights for government agencies and health policymakers to develop contextually appropriate interventions aligned with China's national circumstances, ultimately facilitating improved tetanus vaccination coverage.
关于该主题已知的信息有哪些？：中国破伤风的发病率仍显著高于经济发达地区。破伤风疫苗接种是预防破伤风最科学有效的方法。然而，疫苗犹豫对中国非新生儿破伤风疫苗接种计划的广泛实施构成了重大障碍。
本报告新增了哪些内容？：本研究首次全面调查了中国破伤风疫苗犹豫情况，记录了其当前的流行程度和潜在决定因素。研究结果表明，对破伤风疫苗的了解有限、对破伤风风险的自满情绪、高龄以及其他因素显著导致了疫苗犹豫。该研究表明，提供基于证据的破伤风预防信息的医疗机构和医护人员可能会大幅提高疫苗接种率。
对公共卫生实践有何启示？：通过阐明创伤患者拒绝接种破伤风疫苗的具体原因，本研究为政府机构和卫生政策制定者提供了关键见解，以便制定符合中国国情的适当干预措施，最终促进提高破伤风疫苗接种覆盖率。
