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本文引用的文献

1
DNA and RNA oligomer thermodynamics: the effect of mismatched bases on double-helix stability.DNA和RNA寡聚物热力学：错配碱基对双螺旋稳定性的影响。
Biopolymers. 1981 Dec;20(12):2509-31. doi: 10.1002/bip.1981.360201204.
2
Helical periodicity of DNA, Poly(dA) . poly(dT) and poly(dA-dT). poly(dA-dT) in solution.溶液中DNA、聚（dA）·聚（dT）和聚（dA-dT）·聚（dA-dT）的螺旋周期性。
Eur J Biochem. 1981 Aug;118(2):215-22. doi: 10.1111/j.1432-1033.1981.tb06389.x.
3
Calorimetric determination of base-stacking enthalpies in double-helical DNA molecules.量热法测定双螺旋DNA分子中的碱基堆积焓
Biopolymers. 1982 Nov;21(11):2185-94. doi: 10.1002/bip.360211107.
4
Extra adenosine stacks into the self-complementary d(CGCAGAATTCGCG) duplex in solution.在溶液中，额外的腺苷堆积到自身互补的d(CGCAGAATTCGCG)双链体中。
Biochemistry. 1982 Feb 2;21(3):445-51. doi: 10.1021/bi00532a004.
5
Structure, dynamics, and energetics of deoxyguanosine . thymidine wobble base pair formation in the self-complementary d(CGTGAATTCGCG) duplex in solution.溶液中自互补双链体d(CGTGAATTCGCG) 中脱氧鸟苷-胸苷摆动碱基对形成的结构、动力学和能量学
Biochemistry. 1982 Feb 2;21(3):437-44. doi: 10.1021/bi00532a003.
6
Premelting and melting transitions in the d(CGCGAATTCGCG) self-complementary duplex in solution.溶液中d(CGCGAATTCGCG)自互补双链体的预熔解和熔解转变
Biochemistry. 1982 Feb 2;21(3):428-36. doi: 10.1021/bi00532a002.
7
Heteronomous DNA.异源DNA
Nucleic Acids Res. 1983 Jun 25;11(12):4141-55. doi: 10.1093/nar/11.12.4141.
8
The effect of single base-pair mismatches on the duplex stability of d(T-A-T-T-A-A-T-A-T-C-A-A-G-T-T-G) . d(C-A-A-C-T-T-G-A-T-A-T-T-A-A-T-A).单个碱基对错配 对 d(T-A-T-T-A-A-T-A-T-C-A-A-G-T-T-G) . d(C-A-A-C-T-T-G-A-T-A-T-T-A-A-T-A)双链稳定性的影响
Eur J Biochem. 1984 Feb 15;139(1):19-27. doi: 10.1111/j.1432-1033.1984.tb07970.x.
9
Detection of a guanine X adenine base pair in a decadeoxyribonucleotide by proton magnetic resonance spectroscopy.通过质子磁共振光谱法检测脱氧核糖核苷酸中的鸟嘌呤X腺嘌呤碱基对。
Proc Natl Acad Sci U S A. 1983 Jul;80(14):4263-5. doi: 10.1073/pnas.80.14.4263.
10
Molecular-mechanical studies of the mismatched base analogs of d(CGCGAATTCGCG)2:d(CGTGAATTCGCG)2, d(CGAGAATTCGCG)2, d(CGCGAATTCACG)2, d(CGCGAATTCTCG)2, and d(CGCAGAATTCGCG).d(CGCGAATTCGCG).d(CGCGAATTCGCG)2:d(CGTGAATTCGCG)2、d(CGAGAATTCGCG)2、d(CGCGAATTCACG)2、d(CGCGAATTCTCG)2以及d(CGCAGAATTCGCG).d(CGCGAATTCGCG)错配碱基类似物的分子力学研究
Biopolymers. 1984 Dec;23(12):2901-29. doi: 10.1002/bip.360231214.

碱基-碱基错配。dCA3XA3G + dCT3YT3G（X、Y = A、C、G、T）双螺旋形成的热力学

Base-base mismatches. Thermodynamics of double helix formation for dCA3XA3G + dCT3YT3G (X, Y = A,C,G,T).

作者信息

Aboul-ela F, Koh D, Tinoco I, Martin F H

出版信息

Nucleic Acids Res. 1985 Jul 11;13(13):4811-24. doi: 10.1093/nar/13.13.4811.

DOI:10.1093/nar/13.13.4811
PMID:4022774
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC321828/
Abstract

Thermodynamic parameters for double strand formation have been measured for the sixteen double helices of the sequence dCA3XA3G.dCT3YT3G, with each of the bases A, C, G and T at the positions labelled X and Y. The results are analyzed in terms of nearest-neighbors and are compared with thermodynamic parameters for RNA secondary structure. At room temperature the sequence (Formula: see text) is more stable than (Formula: see text) and is similar in stability to (Formula: see text) and (Formula: see text) are least stable. At higher temperatures the sequences containing a G.C base pair become more stable than those containing only A.T. All molecules containing mismatches are destabilized with respect to those with only Watson-Crick pairing, but there is a wide range of destabilization. At room temperature the most stable mismatches are those containing guanine (G.T, G.G, G.A); the least stable contain cytosine (C.A, C.C). At higher temperatures pyrimidine-pyrimidine mismatches become the least stable.

摘要

已对序列为dCA3XA3G.dCT3YT3G的16个双螺旋进行了双链形成的热力学参数测定，其中碱基A、C、G和T分别位于标记为X和Y的位置。根据最近邻对结果进行了分析，并与RNA二级结构的热力学参数进行了比较。在室温下，序列（公式：见正文）比（公式：见正文）更稳定，并且与（公式：见正文）稳定性相似，而（公式：见正文）最不稳定。在较高温度下，含有G.C碱基对的序列比仅含有A.T的序列更稳定。所有含有错配的分子相对于仅具有沃森-克里克配对的分子都不稳定，但不稳定程度范围很广。在室温下，最稳定的错配是那些含有鸟嘌呤的（G.T、G.G、G.A）；最不稳定的含有胞嘧啶（C.A、C.C）。在较高温度下，嘧啶-嘧啶错配变得最不稳定。