Giroux E, Schechter P J, Schoun J, Sjoerdsma A
Eur J Clin Invest. 1977 Feb;7(1):71-3. doi: 10.1111/j.1365-2362.1977.tb01573.x.
Binding of zinc to macromolecules when added to serum was measured by ultrafiltration. At a final ratio of 0.6 mol zinc per mol albumin, zinc dissociable by glycine was significantly greater in diluted serum from patients with decompensated alcoholic cirrhosis than in normal serum samples similarly prepared. Low serum zinc concentrations, often observed in patients with alcoholic cirrhosis, may be related in part to a reduced affinity of plasma albumin for exchangeable zinc.
通过超滤法测定添加到血清中的锌与大分子的结合情况。在锌与白蛋白的最终摩尔比为0.6时，失代偿期酒精性肝硬化患者稀释血清中可被甘氨酸解离的锌明显高于同样制备的正常血清样本。酒精性肝硬化患者中经常观察到的低血清锌浓度，可能部分与血浆白蛋白对可交换锌的亲和力降低有关。
