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C型利钠肽通过NPRB-PPAR途径调节鸡肌肉和皮下脂肪细胞的脂质代谢。

C-type natriuretic peptide regulates lipid metabolism through a NPRB-PPAR pathway in the intramuscular and subcutaneous adipocytes in chickens.

作者信息

Huang Huayun, Liu Longzhou, Liang Zhong, Wang Qianbao, Li Chunmiao, Huang Zhengyang, Zhao Zhenhua, Han Wei

机构信息

Institute of Poultry Science, Chinese Academy of Agriculture Sciences, 225125, Jiangsu, P. R. China.

College of Animal Science, Yangtze University, Jingzhou, 8060550, P. R. China.

出版信息

Sci Rep. 2025 Apr 15;15(1):13018. doi: 10.1038/s41598-025-86433-w.

DOI:10.1038/s41598-025-86433-w
PMID:40234429
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12000514/
Abstract

Natriuretic peptides (NPs) have an important role in lipid metabolism in skeletal muscle and adipose tissue in animals. C-type natriuretic peptide (CNP) is an important NP, but the molecular mechanisms that underlie its activity are not completely understood. Treatment of intramuscular fat (IMF) and subcutaneous fat (SCF) adipocytes with CNP led to decreased differentiation, promoted proliferation and lipolysis, and increased the expression of natriuretic peptide receptor B (NPRB) mRNA. Silencing natriuretic peptide C (NPPC) had the opposite results in IMF and SCF adipocytes. Transcriptome analysis found 665 differentially expressed genes (DEGs) in IMF adipocytes and 991 in SCF adipocytes. Seven genes in IMF adipocytes (FABP4, APOA1, ACOX2, ADIPOQ, CD36, FABP5, and LPL) and eight genes in SCF adipocytes (ACOX3, ACSL1, APOA1, CPT1A, CPT2, FABP4, PDPK1 and PPARα) are related to fat metabolism. Fifteen genes were found to be enriched in the peroxisome proliferator-activated receptor (PPAR) pathway. Integrated analysis identified 113 intersection genes in IMF and SCF adipocytes, two of which (APOA1 and FABP4) were enriched in the PPAR pathway. In conclusion, CNP may regulated lipid metabolism through the NPRB-PPAR pathway in both IMF and SCF adipocytes, FABP4 and APOA1 may be the key genes that mediated CNP regulation of fat deposition.

摘要

利钠肽（NPs）在动物骨骼肌和脂肪组织的脂质代谢中发挥着重要作用。C型利钠肽（CNP）是一种重要的利钠肽，但其活性的分子机制尚未完全明确。用CNP处理肌内脂肪（IMF）和皮下脂肪（SCF）脂肪细胞，可导致分化减少、增殖和脂肪分解增加，并使利钠肽受体B（NPRB）mRNA的表达增加。沉默利钠肽C（NPPC）在IMF和SCF脂肪细胞中产生相反的结果。转录组分析发现，IMF脂肪细胞中有665个差异表达基因（DEGs），SCF脂肪细胞中有991个。IMF脂肪细胞中的7个基因（FABP4、APOA1、ACOX2、ADIPOQ、CD36、FABP5和LPL）和SCF脂肪细胞中的8个基因（ACOX3、ACSL1、APOA1、CPT1A、CPT2、FABP4、PDPK1和PPARα）与脂肪代谢有关。发现有15个基因在过氧化物酶体增殖物激活受体（PPAR）途径中富集。综合分析在IMF和SCF脂肪细胞中鉴定出113个交集基因，其中两个（APOA1和FABP4）在PPAR途径中富集。总之，CNP可能通过NPRB-PPAR途径在IMF和SCF脂肪细胞中调节脂质代谢，FABP4和APOA1可能是介导CNP调节脂肪沉积的关键基因。

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