胆瘘对大鼠维生素B12吸收的影响。

Effect of bile fistulae on vitamin B12 absorption in rats.

作者信息

Bergesen O, Schjønsby H, Schjerven L

出版信息

Scand J Gastroenterol. 1985 Jun;20(5):589-94. doi: 10.3109/00365528509089701.

Abstract

To study the effect of bile on the absorption of vitamin B12, choledochocolic fistulae were made in 26 rats, and 14 rats were sham-operated. Vitamin B12 absorption 9 days after the operation was significantly reduced in the fistula-operated group (median, 36.4%; range, 8.3-61.4%) as compared with the sham-operated group (median, 48.5; range, 35.8-75.2). Bile instilled together with vitamin B12 did not increase the absorption. In a second 'short-term' experiment external bile fistulae were made in 20 rats, and 10 rats were sham-operated. Vitamin B12 absorption was measured 14 h after the operation, and in this experiment no reduction was found in the fistula-operated rats. This suggests that bile in the lumen of the small intestine has no direct effect on vitamin B12 absorption, but absence of bile during several days may alter other factors of importance for the absorption.

摘要

为研究胆汁对维生素B12吸收的影响，对26只大鼠制作了胆总管结肠瘘，14只大鼠进行假手术。与假手术组（中位数48.5%；范围35.8 - 75.2%）相比，造瘘手术组术后9天的维生素B12吸收显著降低（中位数36.4%；范围8.3 - 61.4%）。与维生素B12一起注入的胆汁并未增加吸收。在第二个“短期”实验中，对20只大鼠制作了外部胆瘘，10只大鼠进行假手术。术后14小时测量维生素B12吸收，在该实验中未发现造瘘大鼠吸收降低。这表明小肠腔内的胆汁对维生素B12吸收没有直接影响，但数天内缺乏胆汁可能会改变其他对吸收很重要的因素。