Bergesen O, Schjønsby H, Schjerven L
Medical Dept., Aker University Hospital, Oslo, Norway.
Scand J Gastroenterol. 1990 Mar;25(3):276-80.
The influence of calcium on vitamin B12 absorption was investigated in two experiments. In the first we investigated whether B12 malabsorption in rats with biliary diversion through choledochocolic fistula is caused by deficiency of calcium in the small intestine. Calcium concentrations were measured in 10 fistula- and 10 sham-operated rats. Fistula rats had steatorrhea, but the concentration of calcium in the intestinal lumen was increased. In the second experiment we studied the effect of calcium deficiency on B12 absorption. Ten young rats were fed a low-calcium diet and 10 rats a control diet for 4 weeks. Rats on the low-calcium diet had moderately reduced calcium concentration in the blood and in the intestinal juice but unaltered calcium concentration in the cytosol fraction of intestinal mucosal scrapings. The absorption of 57CoB12 was unimpaired. This suggests that moderate calcium deficiency does not influence the intestinal absorption of vitamin B12 in the rat.
在两项实验中研究了钙对维生素B12吸收的影响。在第一个实验中，我们研究了通过胆总管结肠瘘进行胆汁分流的大鼠中维生素B12吸收不良是否由小肠钙缺乏引起。测量了10只瘘管大鼠和10只假手术大鼠的钙浓度。瘘管大鼠有脂肪泻，但肠腔内钙浓度升高。在第二个实验中，我们研究了钙缺乏对维生素B12吸收的影响。10只幼鼠喂食低钙饮食，10只大鼠喂食对照饮食4周。低钙饮食的大鼠血液和肠液中的钙浓度适度降低，但肠黏膜刮片细胞溶质部分的钙浓度未改变。57CoB12的吸收未受损害。这表明中度钙缺乏不会影响大鼠肠道对维生素B12的吸收。
