一项关于碳酸酐酶自身抗体在纤维肌痛发病机制及诊断中作用的病例对照研究。
A case-control study on the role of carbonic anhydrase autoantibodies in the pathogenesis and diagnosis of fibromyalgia.
作者信息
Kılıç Hülya, Hasanova Narmin, Topaloğlu Mehmet Serhat, Şahin Elif, Sağlam Neslihan, Alemdar Nihal Türkmen, Menteşe Ahmet
机构信息
Department of Medical Biochemistry, Medicine Faculty of Recep Tayyip Erdoğan University, Rize, 53020, Turkey.
Department of Physical Medicine and Rehabilitation, Medicine Faculty of Recep Tayyip Erdoğan University, Rize, 53020, Turkey.
出版信息
Sci Rep. 2025 Apr 16;15(1):13158. doi: 10.1038/s41598-025-96677-1.
To investigate the levels and diagnostic significance of carbonic anhydrase I (CAI) and II (CAII) autoantibodies and oxidative stress status in fibromyalgia syndrome (FMS) patients. A total of 59 FMS patients and 53 healthy controls were included. CAI and CAII autoantibody levels were measured using a manual ELISA protocol. Serum malondialdehyde (MDA), serum total oxidant status (TOS), serum total antioxidant status (TAS), and oxidative stress index (OSI) were also analyzed. The mean CAI and CAII autoantibody levels were significantly higher in the FMS group compared to the control group (p < 0.000 and p < 0.003, respectively). FMS patients had significantly higher MDA, TOS and OSI levels(p < 0.000 for all comparisons), and lower TAS levels compared to controls but no significant differences (p > 0,705). Elevated CAI and CAII autoantibodies and altered oxidative stress markers in FMS patients suggest autoimmune processes and oxidative stress involvement in the pathogenesis of FMS, providing new insights into potential diagnostic and therapeutic approaches.
探讨纤维肌痛综合征（FMS）患者碳酸酐酶I（CAI）和II（CAII）自身抗体水平、氧化应激状态及其诊断意义。共纳入59例FMS患者和53例健康对照者。采用手工酶联免疫吸附测定法检测CAI和CAII自身抗体水平。同时分析血清丙二醛（MDA）、血清总氧化状态（TOS）、血清总抗氧化状态（TAS）和氧化应激指数（OSI）。FMS组的CAI和CAII自身抗体平均水平显著高于对照组（分别为p < 0.000和p < 0.003）。与对照组相比，FMS患者的MDA、TOS和OSI水平显著升高（所有比较均为p < 0.000），TAS水平较低，但差异无统计学意义（p > 0.705）。FMS患者CAI和CAII自身抗体升高以及氧化应激标志物改变提示自身免疫过程和氧化应激参与FMS的发病机制，为潜在的诊断和治疗方法提供了新的见解。
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