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对移动mRNA数据集的重新分析引发了关于长距离mRNA通讯程度的问题。

Re-analysis of mobile mRNA datasets raises questions about the extent of long-distance mRNA communication.

作者信息

Paajanen Pirita, Tomkins Melissa, Hoerbst Franziska, Veevers Ruth, Heeney Michelle, Thomas Hannah Rae, Apelt Federico, Saplaoura Eleftheria, Gupta Saurabh, Frank Margaret, Walther Dirk, Faulkner Christine, Kehr Julia, Kragler Friedrich, Morris Richard J

机构信息

Computational and Systems Biology, John Innes Centre, Norwich, UK.

School of Integrative Plant Science, Cornell University, Ithaca, NY, USA.

出版信息

Nat Plants. 2025 May;11(5):977-984. doi: 10.1038/s41477-025-01979-x. Epub 2025 Apr 16.

DOI:10.1038/s41477-025-01979-x
PMID:40240650
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12095074/
Abstract

Short-read RNA-seq studies of grafted plants have led to the proposal that thousands of messenger RNAs (mRNAs) move over long distances between plant tissues, potentially acting as signals. Transport of mRNAs between cells and tissues has been shown to play a role in several physiological and developmental processes in plants, such as tuberization, leaf development and meristem maintenance; yet for most mobile mRNAs, the biological relevance of transport remains to be determined. Here we perform a meta-analysis of existing mobile mRNA datasets and examine the associated bioinformatic pipelines. Taking technological noise, biological variation, potential contamination and incomplete genome assemblies into account, we find that a high percentage of currently annotated graft-mobile transcripts are left without statistical support from available RNA-seq data. This meta-analysis challenges the findings of previous studies and current views on mRNA communication.

摘要

对嫁接植物的短读长RNA测序研究提出，数千种信使核糖核酸（mRNA）在植物组织间长距离移动，可能充当信号。mRNA在细胞和组织间的运输已被证明在植物的多个生理和发育过程中发挥作用，如块茎形成、叶片发育和分生组织维持；然而，对于大多数可移动的mRNA，其运输的生物学相关性仍有待确定。在这里，我们对现有的可移动mRNA数据集进行了荟萃分析，并检查了相关的生物信息学流程。考虑到技术噪声、生物学变异、潜在污染和不完整的基因组组装，我们发现目前注释的嫁接可移动转录本中有很大一部分没有得到现有RNA测序数据的统计支持。这项荟萃分析对先前研究的结果和目前关于mRNA通讯的观点提出了挑战。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b23d/12095074/3d069084e7dc/41477_2025_1979_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b23d/12095074/824a21444a2d/41477_2025_1979_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b23d/12095074/e3b0fec71e9e/41477_2025_1979_Fig4_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b23d/12095074/3c4da0f6329b/41477_2025_1979_Fig5_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b23d/12095074/e6dc552e165e/41477_2025_1979_Fig6_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b23d/12095074/c9bba58b7201/41477_2025_1979_Fig7_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b23d/12095074/d65437f4b0cb/41477_2025_1979_Fig8_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b23d/12095074/b2fb8a03dc8a/41477_2025_1979_Fig9_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b23d/12095074/fddb92411475/41477_2025_1979_Fig10_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b23d/12095074/de08c39a69bd/41477_2025_1979_Fig11_ESM.jpg

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2
Artifacts and biases of the reverse transcription reaction in RNA sequencing.RNA 测序中反转录反应的假象和偏差。
RNA. 2023 Jul;29(7):889-897. doi: 10.1261/rna.079623.123. Epub 2023 Mar 29.
3
Extensive sequence duplication in Arabidopsis revealed by pseudo-heterozygosity.拟杂合性揭示拟南芥中广泛的序列重复。
Genome Biol. 2023 Mar 9;24(1):44. doi: 10.1186/s13059-023-02875-3.
4
The mRNA mobileome: challenges and opportunities for deciphering signals from the noise.mRNA 移动组学：从噪声中破译信号的挑战和机遇。
Plant Cell. 2023 May 29;35(6):1817-1833. doi: 10.1093/plcell/koad063.
5
Heritable transgene-free genome editing in plants by grafting of wild-type shoots to transgenic donor rootstocks.通过将野生型茎嫁接到转基因供体砧木上来实现植物中可遗传的无转基因基因编辑。
Nat Biotechnol. 2023 Jul;41(7):958-967. doi: 10.1038/s41587-022-01585-8. Epub 2023 Jan 2.
6
Exact Bayesian inference for the detection of graft-mobile transcripts from sequencing data.从测序数据中检测移植物-移动转录本的精确贝叶斯推断。
J R Soc Interface. 2022 Dec;19(197):20220644. doi: 10.1098/rsif.2022.0644. Epub 2022 Dec 14.
7
An RNA exosome subunit mediates cell-to-cell trafficking of a homeobox mRNA via plasmodesmata.RNA 外切体亚基通过胞间连丝介导同源盒 mRNA 的细胞间运输。
Science. 2022 Jan 14;375(6577):177-182. doi: 10.1126/science.abm0840. Epub 2022 Jan 13.
8
Long-Distance Transported RNAs: From Identity to Function.长距离转运 RNA：从身份到功能。
Annu Rev Plant Biol. 2022 May 20;73:457-474. doi: 10.1146/annurev-arplant-070121-033601. Epub 2021 Dec 15.
9
Ensembl Genomes 2022: an expanding genome resource for non-vertebrates.Ensembl Genomes 2022：一个不断扩展的非脊椎动物基因组资源。
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10
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NAR Genom Bioinform. 2021 Mar 27;3(1):lqab019. doi: 10.1093/nargab/lqab019. eCollection 2021 Mar.