Kumano N, Ishikawa T, Koinumaru S, Kikumoto T, Suzuki S, Nakai Y, Konno K
Tohoku J Exp Med. 1985 May;146(1):97-104. doi: 10.1620/tjem.146.97.
Effects of the organogermanium compound Ge-132 (i.p.) were examined on the 3LL local tumor (1 X 10(5)/mouse, s.c.) and its pulmonary metastases in B6 mice. A characteristic feature of its action was the preferential antimetastatic effect under strictly defined conditions. Either inhibition or facilitation was observed depending on the treatment schedules; 7 daily doses of 100 mg/kg yielded the inhibition ratio 49% when started from day 1, whereas the treatment from day 8 resulted in the ratio -99%. The maximum inhibition was obtained at 100 mg/kg. The postsurgical-adjuvant treatment with Ge-132 was of no beneficial effect. The local tumor growth was affected only marginally and temporarily. When inoculum size was minimized (1 X 10(4)), a single dose of 300 mg/kg on day 1, but not on day 8, was effective in prolonging the latency before tumor take. The antitumor action of Ge-132 was discussed with reference to its interferon (IFN)-inducing activity.
研究了有机锗化合物Ge - 132腹腔注射对B6小鼠3LL局部肿瘤（皮下接种，每只小鼠1×10⁵个细胞）及其肺转移的影响。其作用的一个特点是在严格限定条件下具有优先的抗转移作用。根据治疗方案的不同，观察到的结果既有抑制作用，也有促进作用；从第1天开始，连续7天每天给予100 mg/kg，抑制率为49%，而从第8天开始治疗，抑制率为 - 99%。在100 mg/kg时获得最大抑制效果。Ge - 132的术后辅助治疗没有益处。局部肿瘤生长仅受到轻微且短暂的影响。当接种量减至最小（1×10⁴）时，第1天给予300 mg/kg的单次剂量有效延长了肿瘤接种后的潜伏期，但第8天给药则无效。参照其诱导干扰素（IFN）的活性对Ge - 132的抗肿瘤作用进行了讨论。
