刺突蛋白与纤维蛋白原的相互作用：新型冠状病毒的一种免疫逃逸策略？
Spike Protein-Fibrinogen Interaction: A Novel Immune Evasion Strategy of SARS-CoV-2?
作者信息
Panda Saroj Kumar, Singh Shashi, Sen Gupta Parth Sarthi
机构信息
Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, Texas 76013, United States.
School of Biosciences and Bioengineering, D Y Patil International University (DYPIU), Akurdi, Pune, Maharashtra 411044, India.
出版信息
ACS Pharmacol Transl Sci. 2025 Mar 19;8(4):1182-1184. doi: 10.1021/acsptsci.5c00122. eCollection 2025 Apr 11.
Abstract
The host protein fibrinogen has been found to interact with the N-terminal domain (NTD) of the spike protein in SARS-CoV-2. However, the evolutionary benefit of this binding to the virus still remains unclear. Herein, we put forward with rationale and supporting evidence that the binding of fibrinogen to its more conserved NTD is an immune evasion strategy adopted by the virus to outsmart the NTD targeted neutralizing antibodies.
摘要
已发现宿主蛋白纤维蛋白原可与严重急性呼吸综合征冠状病毒2（SARS-CoV-2）刺突蛋白的N端结构域（NTD）相互作用。然而，这种结合对病毒的进化益处仍不清楚。在此，我们提出了合理依据和支持证据，即纤维蛋白原与其更保守的NTD的结合是病毒采用的一种免疫逃避策略，以智胜靶向NTD的中和抗体。
相似文献
1
Spike Protein-Fibrinogen Interaction: A Novel Immune Evasion Strategy of SARS-CoV-2?刺突蛋白与纤维蛋白原的相互作用：新型冠状病毒的一种免疫逃逸策略？
ACS Pharmacol Transl Sci. 2025 Mar 19;8(4):1182-1184. doi: 10.1021/acsptsci.5c00122. eCollection 2025 Apr 11.
2
Antibody tests for identification of current and past infection with SARS-CoV-2.抗体检测用于鉴定 SARS-CoV-2 的现症感染和既往感染。
Cochrane Database Syst Rev. 2022 Nov 17;11(11):CD013652. doi: 10.1002/14651858.CD013652.pub2.
3
Determinants of susceptibility to SARS-CoV-2 infection in murine ACE2.小鼠血管紧张素转换酶2（ACE2）对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染易感性的决定因素。
J Virol. 2025 Jun 17;99(6):e0054325. doi: 10.1128/jvi.00543-25. Epub 2025 May 12.
4
Exploring Diverse Binding Mechanisms of Broadly Neutralizing Antibodies S309, S304, CYFN-1006 and VIR-7229 Targeting SARS-CoV-2 Spike Omicron Variants: Integrative Computational Modeling Reveals Balance of Evolutionary and Dynamic Adaptability in Shaping Molecular Determinants of Immune Escape.探索靶向SARS-CoV-2刺突奥密克戎变体的广泛中和抗体S309、S304、CYFN-1006和VIR-7229的多种结合机制：综合计算模型揭示了在塑造免疫逃逸分子决定因素中进化适应性和动态适应性的平衡。
bioRxiv. 2025 Apr 17:2025.04.15.649027. doi: 10.1101/2025.04.15.649027.
5
Signs and symptoms to determine if a patient presenting in primary care or hospital outpatient settings has COVID-19.在基层医疗机构或医院门诊环境中，如果患者出现以下症状和体征，可判断其是否患有 COVID-19。
Cochrane Database Syst Rev. 2022 May 20;5(5):CD013665. doi: 10.1002/14651858.CD013665.pub3.
6
The pan-variant potential of light: 425 nm light inactivates SARS-CoV-2 variants of concern and non-cytotoxic doses reduce viral titers in human airway epithelial cells.光的泛变体潜力：425纳米的光可使新冠病毒变异株失活，且非细胞毒性剂量可降低人气道上皮细胞中的病毒滴度。
mSphere. 2025 Jun 25;10(6):e0023025. doi: 10.1128/msphere.00230-25. Epub 2025 May 28.
7
Dihydrotanshinone I targets the spike N-terminal domain to inhibit SARS-CoV-2 entry and spike-induced inflammation.二氢丹参酮 I 靶向刺突蛋白 N 端结构域以抑制 SARS-CoV-2 进入及刺突蛋白诱导的炎症反应。
Phytomedicine. 2025 Sep;145:156989. doi: 10.1016/j.phymed.2025.156989. Epub 2025 Jun 17.
8
Physical interventions to interrupt or reduce the spread of respiratory viruses.物理干预措施以阻断或减少呼吸道病毒的传播。
Cochrane Database Syst Rev. 2023 Jan 30;1(1):CD006207. doi: 10.1002/14651858.CD006207.pub6.
9
Quantitative characterisation of extracellular vesicles designed to decoy or compete with SARS-CoV-2 reveals differential mode of action across variants of concern and highlights the diversity of Omicron.旨在与严重急性呼吸综合征冠状病毒2（SARS-CoV-2）诱饵或竞争的细胞外囊泡的定量表征揭示了针对不同关注变体的不同作用模式，并突出了奥密克戎的多样性。
Cell Commun Signal. 2025 Jul 2;23(1):323. doi: 10.1186/s12964-025-02223-x.
10
The impact of clade B lineage 5 MERS coronaviruses spike mutations from 2015 to 2023 on virus entry and replication competence.2015年至2023年B类5型中东呼吸综合征冠状病毒刺突蛋白突变对病毒进入和复制能力的影响。
bioRxiv. 2025 Jul 1:2025.06.30.662263. doi: 10.1101/2025.06.30.662263.
本文引用的文献
1
SARS-CoV-2 evolution on a dynamic immune landscape.严重急性呼吸综合征冠状病毒2在动态免疫环境中的进化
Nature. 2025 Mar;639(8053):196-204. doi: 10.1038/s41586-024-08477-8. Epub 2025 Jan 29.
2
Fibrin drives thromboinflammation and neuropathology in COVID-19.纤维蛋白导致 COVID-19 中的血栓炎症和神经病理学。
Nature. 2024 Sep;633(8031):905-913. doi: 10.1038/s41586-024-07873-4. Epub 2024 Aug 28.
3
Accurate structure prediction of biomolecular interactions with AlphaFold 3.利用 AlphaFold 3 进行生物分子相互作用的精确结构预测。
Nature. 2024 Jun;630(8016):493-500. doi: 10.1038/s41586-024-07487-w. Epub 2024 May 8.
4
Broadly neutralizing antibodies to SARS-CoV-2 and other human coronaviruses.广谱中和抗体对 SARS-CoV-2 和其他人类冠状病毒。
Nat Rev Immunol. 2023 Mar;23(3):189-199. doi: 10.1038/s41577-022-00784-3. Epub 2022 Sep 27.
5
SARS-CoV-2 variants of concern: spike protein mutational analysis and epitope for broad neutralization.关注的 SARS-CoV-2 变体：刺突蛋白突变分析和广谱中和的表位。
Nat Commun. 2022 Aug 18;13(1):4696. doi: 10.1038/s41467-022-32262-8.
6
N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2.N 端结构域抗原性分析揭示了 SARS-CoV-2 的一个弱点。
Cell. 2021 Apr 29;184(9):2332-2347.e16. doi: 10.1016/j.cell.2021.03.028. Epub 2021 Mar 16.
7
Neutralizing antibodies targeting SARS-CoV-2 spike protein.靶向严重急性呼吸综合征冠状病毒2（SARS-CoV-2）刺突蛋白的中和抗体。
Stem Cell Res. 2020 Dec 15;50:102125. doi: 10.1016/j.scr.2020.102125.
8
A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2.一种中和性人源抗体结合到了 SARS-CoV-2 的刺突蛋白的 N 端结构域。
Science. 2020 Aug 7;369(6504):650-655. doi: 10.1126/science.abc6952. Epub 2020 Jun 22.
9
Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein.严重急性呼吸系统综合征冠状病毒 2 刺突糖蛋白的结构、功能和抗原性。
Cell. 2020 Apr 16;181(2):281-292.e6. doi: 10.1016/j.cell.2020.02.058. Epub 2020 Mar 9.
10
PRODIGY: a web server for predicting the binding affinity of protein-protein complexes.PRODIGY：一个用于预测蛋白质-蛋白质复合物结合亲和力的网络服务器。
Bioinformatics. 2016 Dec 1;32(23):3676-3678. doi: 10.1093/bioinformatics/btw514. Epub 2016 Aug 8.
Zotero 插件