Panda Saroj Kumar, Singh Shashi, Sen Gupta Parth Sarthi
Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, Texas 76013, United States.
School of Biosciences and Bioengineering, D Y Patil International University (DYPIU), Akurdi, Pune, Maharashtra 411044, India.
ACS Pharmacol Transl Sci. 2025 Mar 19;8(4):1182-1184. doi: 10.1021/acsptsci.5c00122. eCollection 2025 Apr 11.
The host protein fibrinogen has been found to interact with the N-terminal domain (NTD) of the spike protein in SARS-CoV-2. However, the evolutionary benefit of this binding to the virus still remains unclear. Herein, we put forward with rationale and supporting evidence that the binding of fibrinogen to its more conserved NTD is an immune evasion strategy adopted by the virus to outsmart the NTD targeted neutralizing antibodies.
已发现宿主蛋白纤维蛋白原可与严重急性呼吸综合征冠状病毒2（SARS-CoV-2）刺突蛋白的N端结构域（NTD）相互作用。然而，这种结合对病毒的进化益处仍不清楚。在此，我们提出了合理依据和支持证据，即纤维蛋白原与其更保守的NTD的结合是病毒采用的一种免疫逃避策略，以智胜靶向NTD的中和抗体。
