Büttner J
J Clin Chem Clin Biochem. 1977 Jan;15(1):1-12.
Little attention has been paid before to the diagnostic efficiency of clinical chemical tests. In view of the ever increasing number of clinical chemical analyses and the critical development of expenses in medical health care, an evaluation of this aspect of clinical chemical analyses seems to be urgently required. Various new methods, that might be used, are reviewed. Qualitative and quantiative tests, and the so-called multiple analysis are discussed as examples of clinical chemical methods. The necessary mathematical treatments (use of the Bayes theorem, information theory, likelihood ratio method, and others) are illustrated with the aid of worked examples. A new cost-effectiveness analysis of clinical chemical data is suggested.
以往对临床化学检验的诊断效率关注甚少。鉴于临床化学分析数量不断增加以及医疗保健费用的关键发展情况，对临床化学分析这一方面的评估似乎迫切需要。文中综述了各种可能使用的新方法。作为临床化学方法的示例，讨论了定性和定量检验以及所谓的多重分析。借助实例说明了必要的数学处理方法（贝叶斯定理、信息论、似然比方法等的应用）。提出了对临床化学数据的一种新的成本效益分析方法。
