Qureshi S, al-Harbi M M, Ahmed M M, Raza M, Giangreco A B, Shah A H
Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Cancer Chemother Pharmacol. 1993;33(2):130-8. doi: 10.1007/BF00685330.
The genotoxic, cytotoxic and antitumor properties of Commiphora molmol (oleo gum resin) were studied in normal and Ehrlich ascites carcinoma cell-bearing mice. In normal mice, the genotoxic and cytotoxic activity was evaluated on the bases of the frequency of micronuclei and the ratio of polychromatic to normochromatic cells in bone marrow, which was substantiated by the biochemical changes in hepatic cells. The antitumor activity of C. molmol was evaluated from the total count and viability of Ehrlich ascites carcinoma cells and their nucleic acid, protein, malondialdehyde, and elemental concentrations in addition to observations on survival and the trend of changes in body weight. The tumors at the site of injection were evaluated for histopathological changes. Treatment with C. molmol (125-500 mg/kg) showed no clastogenicity but was found to be highly cytotoxic in normal mice. The results obtained in the Ehrlich ascites carcinoma cell-bearing mice revealed the cytotoxic and antitumor activity of C. molmol which was found to be equivalent to those of the standard cytotoxic drug cyclophosphamide. On the basis of the nonmutagenic, antioxidative, and cytotoxic potential of C. molmol as observed in the present study, its use in cancer therapy seems to be appropriate and further investigations are suggested.
在正常小鼠和携带艾氏腹水癌的小鼠中研究了没药（油胶树脂）的遗传毒性、细胞毒性和抗肿瘤特性。在正常小鼠中，基于微核频率和骨髓中嗜多染红细胞与正常红细胞的比例评估遗传毒性和细胞毒性活性，肝细胞的生化变化证实了这一点。通过艾氏腹水癌细胞的总数和活力以及它们的核酸、蛋白质、丙二醛和元素浓度，以及对存活情况和体重变化趋势的观察来评估没药的抗肿瘤活性。对注射部位的肿瘤进行组织病理学变化评估。用没药（125 - 500毫克/千克）治疗未显示出致断裂性，但在正常小鼠中发现具有高度细胞毒性。在携带艾氏腹水癌的小鼠中获得的结果显示了没药的细胞毒性和抗肿瘤活性，发现其与标准细胞毒性药物环磷酰胺相当。基于本研究中观察到的没药的非诱变、抗氧化和细胞毒性潜力，其在癌症治疗中的应用似乎是合适的，建议进一步研究。
