Tnimov M Kh, Semeniuk A V, Voronina N P, Shishkina L N, Maianskiĭ D N
Biull Eksp Biol Med. 1984 Nov;98(11):591-3.
The pulmonary tissue of rats exposed to prolonged (8 days) intensive (-7 degrees C) cold was examined for the intensity of lipid peroxidation and activity of pulmonary macrophages. The data obtained during cold exposure attest to activation of the pulmonary compartment of the system of mononuclear phagocytes. Activation of lipid peroxidation in the lungs (days 1-8) associated with inhibition of the antioxidant systems (tocopherol, glutathione) is regarded as a possible mechanism of pulmonary tissue injuring by cold which stimulates the macrophagal response. A possible role of the activated forms of oxygen produced by macrophages during lipid peroxidation stimulation is discussed.
对暴露于长时间（8天）高强度（-7摄氏度）寒冷环境的大鼠肺组织进行了脂质过氧化强度和肺巨噬细胞活性检测。寒冷暴露期间获得的数据证明单核吞噬细胞系统的肺部分被激活。肺中脂质过氧化的激活（第1 - 8天）与抗氧化系统（生育酚、谷胱甘肽）的抑制相关，这被认为是寒冷损伤肺组织并刺激巨噬细胞反应的一种可能机制。文中还讨论了巨噬细胞在刺激脂质过氧化过程中产生的活性氧形式的可能作用。
