使用联合质子密度脂肪分数-R2体模对基于MRI的同步质子密度脂肪分数和R2成像进行多中心、多供应商验证

Multi-Center, Multi-Vendor Validation of Simultaneous MRI-Based Proton Density Fat Fraction and R2* Mapping Using a Combined Proton Density Fat Fraction-R2* Phantom.

作者信息

Starekova Jitka, Rutkowski David, Bae Won C, Do Hung, Madhuranthakam Ananth J, Malis Vadim, Lin Sheng Qing, Serai Suraj, Yokoo Takeshi, Reeder Scott B, Brittain Jean H, Hernando Diego

机构信息

Department of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Calimetrix, Madison, Wisconsin, USA.

出版信息

J Magn Reson Imaging. 2025 Apr 18. doi: 10.1002/jmri.29775.

DOI:10.1002/jmri.29775

PMID:40251801

Abstract

BACKGROUND

Fat and iron deposition confound measurements of R2* and proton density fat fraction (PDFF), respectively, yet their combined impact on reproducibility is poorly understood.

PURPOSE

To evaluate the multi-center, multi-vendor reproducibility of PDFF and R2* quantification using a PDFF-R2* phantom.

STUDY TYPE

Prospective multi-center, phantom study.

PHANTOM

Commercial PDFF-R2* phantom with simultaneously controlled combination of PDFF (0%-30%) and R2* (50-600 s) values.

FIELD STRENGTH/SEQUENCE: 1.5-T and 3-T, three-dimensional (3D) multi-echo, spoiled-gradient-echo sequences, in four different centers, each with a different vendor.

ASSESSMENT

Two acquisition protocols were used, optimized for moderate R2* (Protocol 1) and high R2* (Protocol 2), respectively. The phantom was imaged multiple times at one of the centers to assess its stability.

STATISTICAL TESTS

Intraclass correlation coefficient (ICC), linear regression analysis, reproducibility coefficient (RDC) and repeatability coefficient (RC).

RESULTS

Excellent agreement was observed for PDFF measurements between centers, vendors, field strengths, and protocols (ICC = 0.97). Stratified by protocol, excellent agreement was observed, with ICC = 0.96 (RDC = 6.2%) for Protocol 1 and ICC = 0.99 (RDC = 3.8%) for Protocol 2. Increased variability in PDFF measurements was observed with increasing PDFF and especially with higher R2*. Excellent agreement was observed for R2* between centers, vendors, field strengths, and protocols (ICC = 0.99). Stratified by protocol, strong agreement was observed, with ICC = 0.988 (RDC = 66.7 s) for Protocol 1 and ICC = 0.99 (RDC = 57.7 s) for Protocol 2. Higher variability in R2* measurements was observed in vials with higher PDFF or R2*. Stability tests demonstrated an ICC = 1.0 for PDFF and R2*, and RC of 0.4% for PDFF and 12 s for R2*.

DATA CONCLUSION

Excellent PDFF and R2* reproducibility was observed across centers, vendors, field strengths, and acquisition protocols. Reproducibility decreased slightly with increasing PDFF and R2*, especially for PDFF measurements in vials with high R2*.

EVIDENCE LEVEL

N/A.

TECHNICAL EFFICACY

Stage 1.

摘要

背景

脂肪和铁沉积分别会干扰R2*和质子密度脂肪分数（PDFF）的测量，然而它们对测量可重复性的综合影响却鲜为人知。

目的

使用PDFF-R2体模评估PDFF和R2定量的多中心、多设备可重复性。

研究类型

前瞻性多中心体模研究。

体模

商业化的PDFF-R2体模，可同时控制PDFF（0%-30%）和R2（50-600 s）值的组合。

场强/序列：1.5-T和3-T，三维（3D）多回波扰相梯度回波序列，在四个不同中心进行，每个中心使用不同的设备。

评估

使用了两种采集方案，分别针对中等R2*（方案1）和高R2*（方案2）进行了优化。在其中一个中心对体模进行多次成像以评估其稳定性。

统计检验

组内相关系数（ICC）、线性回归分析、可重复性系数（RDC）和重复性系数（RC）。

结果

在各中心、设备、场强和方案之间，PDFF测量结果具有极好的一致性（ICC = 0.97）。按方案分层，一致性良好，方案1的ICC = 0.96（RDC = 6.2%），方案2的ICC = 0.99（RDC = 3.8%）。随着PDFF增加，尤其是R2升高时，PDFF测量的变异性增加。在各中心、设备、场强和方案之间，R2测量结果具有极好的一致性（ICC = 0.99）。按方案分层，一致性较强，方案1的ICC = 0.988（RDC = 66.7 s），方案2的ICC = 0.99（RDC = 57.7 s）。在PDFF或R2较高的样品瓶中，R2测量的变异性更高。稳定性测试表明，PDFF和R2的ICC = 1.0，PDFF的RC为0.4%，R2的RC为12 s。