Yamaguchi T, Tamaki K, Kaufman H E, Katz J, Shaw E L
Am J Ophthalmol. 1985 Aug 15;100(2):281-92. doi: 10.1016/0002-9394(85)90794-9.
Two corneas were obtained from a man who underwent anterior radial keratotomy in both eyes less than three months before his death. The corneas were obtained and fixed 16 hours after death and prepared for histologic evaluation four days later. Both corneas showed epithelial ingrowth in the surgical wounds, epithelial inclusion cysts in some areas, and ridges or protrusions of the posterior cornea beneath the incisions. The incisions ranged in depth from 48% to 63% of the full thickness of the cornea in the right eye and from 69% to 98% in the left eye, demonstrating the difficulties involved in maintaining a precise and predictable depth of incision, which may, in turn, be related to variations in visual results. Signs of endothelial stress, in the form of collagen and fibrils on the posterior Descemet's membrane, apparently predated the refractive surgery. Precautions such as specular microscopy may be needed to rule out this kind of surgery in patients with the early signs of some types of potential corneal disease.
从一名男性获取了两只角膜，该男性在去世前不到三个月时双眼接受了放射状角膜切开术。角膜在其死后16小时获取并固定，四天后准备进行组织学评估。两只角膜均显示手术伤口处有上皮内生，部分区域有上皮植入囊肿，切口下方后角膜有嵴或凸起。右眼切口深度为角膜全层厚度的48%至63%，左眼为69%至98%，这表明维持精确且可预测的切口深度存在困难，而这反过来可能与视觉结果的差异有关。后弹力层上以胶原和原纤维形式存在的内皮应激迹象显然早于屈光手术。对于有某些类型潜在角膜疾病早期迹象的患者，可能需要采取如角膜内皮镜检查等预防措施以排除此类手术。
