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改善埃塞俄比亚、加纳和肯尼亚无家可归且患有严重精神疾病者的治疗效果:希望项目概述

Improving outcomes for people who are homeless and have severe mental illness in Ethiopia, Ghana and Kenya: overview of the HOPE programme.

作者信息

Hanlon Charlotte, Smartt Caroline, Mutiso Victoria N, Yaro Peter, Misganaw Eleni, Read Ursula, Mayston Rosie, Birhanu Ribka, Dako-Gyeke Phyllis, Ndetei David M, Asher Laura, Repper Julie, Eaton Julian, Chua Kia-Chong, Fekadu Abebaw, Tsigebrhan Ruth, Ashaley Fofo Cecilia, Kariuki Kimberly, Rai Sauharda, Abayneh Sisay, Amissah Caroline Reindorf, Boadu Amma Mpomaa, Makau Priscilla, Tadesse Agitu, Timms Philip, Prince Martin, Thornicroft Graham, Kohrt Brandon, Alem Atalay

机构信息

Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.

Centre for Innovative Drug Development and Therapeutic Trials for Africa (CDT-Africa), College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

出版信息

Epidemiol Psychiatr Sci. 2025 Apr 21;34:e26. doi: 10.1017/S2045796025000186.

Abstract

AIM

HOPE (National Institute for Health and Care Research Global Health Research Group on Homelessness and Mental Health in Africa) aims to develop and evaluate interventions that address the unmet needs of people who are homeless and have severe mental illness (SMI) living in three African countries in ways that are rights-based, contextually grounded, scalable and sustainable.

METHODS

We will work in the capital city (Addis Ababa) in Ethiopia, a regional city (Tamale) in Ghana, and the capital city (Nairobi) and a rural county (Makueni) in Kenya to understand different approaches to intervention needed across varied settings.We will be guided by the MRC/NIHR framework on complex interventions and implementation frameworks and emphasise co-production. Formative work will include synthesis of global evidence (systematic review, including grey literature, and a Delphi consensus exercise) on interventions and approaches to homelessness and SMI. We will map contexts; conduct focused ethnography to understand lived experiences of homelessness and SMI; carry out a cross-sectional survey of people who are homeless (n = 750 Ghana/Ethiopia; n = 350 Kenya) to estimate prevalence of SMI and identify prioritised needs; and conduct in-depth interviews and focus group discussions with key stakeholders to understand experiences, challenges and opportunities for intervention. This global and local evidence will feed into Theory of Change (ToC) workshops with stakeholders to establish agreement about valued primary outcomes, map pathways to impact and inform selection and implementation of interventions. Intervention packages to address prioritised needs will be co-produced, piloted and optimised for feasibility and acceptability using participatory action research. We will use rights-based approaches and focus on community-based care to ensure sustainability. Realist approaches will be employed to analyse how contextual variation affects mechanisms and outcomes to inform methods for a subsequent evaluation of larger scale implementation. Extensive capacity-strengthening activities will focus on equipping early career researchers and peer researchers. People with lived experience of SMI and policymakers are an integral part of the research team. Community engagement is supported by working closely with multisectoral Community Advisory Groups.

CONCLUSIONS

HOPE will develop evidence to support action to respond to the needs and preferences of people experiencing homelessness and SMI in diverse settings in Africa. We are creating a new partnership of researchers, policymakers, community members and people with lived experience of SMI and homelessness to enable African-led solutions. Key outputs will include contextually relevant practice and policy guidance that supports achievement of inclusive development.

摘要

目标

HOPE(英国国家卫生与保健研究所全球健康研究小组,专注于非洲无家可归者与心理健康问题)旨在开发并评估干预措施,以满足三个非洲国家中无家可归且患有严重精神疾病(SMI)人群未被满足的需求,且这些干预措施需基于权利、因地制宜、具有可扩展性和可持续性。

方法

我们将在埃塞俄比亚的首都城市(亚的斯亚贝巴)、加纳的一个地区城市(塔马利)、肯尼亚的首都城市(内罗毕)以及一个农村县(马库埃尼)开展工作,以了解不同环境下所需的不同干预方法。我们将遵循医学研究理事会/英国国家卫生研究所关于复杂干预和实施框架的指导方针,并强调共同生产。形成性工作将包括综合全球证据(系统评价——包括灰色文献,以及德尔菲共识练习),内容涉及针对无家可归和严重精神疾病的干预措施及方法。我们将绘制背景情况;进行重点人种志研究,以了解无家可归和严重精神疾病的实际经历;对无家可归者进行横断面调查(加纳/埃塞俄比亚750人;肯尼亚350人),以估计严重精神疾病的患病率并确定优先需求;与关键利益相关者进行深入访谈和焦点小组讨论,以了解干预的经验、挑战和机会。这些全球和本地的证据将用于与利益相关者开展的变革理论(ToC)研讨会,以就有价值的主要成果达成共识,绘制影响路径,并为干预措施的选择和实施提供信息。针对优先需求的干预方案将通过参与式行动研究共同制定、试点并优化,以确保其可行性和可接受性。我们将采用基于权利的方法,并专注于社区护理以确保可持续性。将运用现实主义方法分析背景差异如何影响机制和结果,为后续大规模实施评估的方法提供信息。广泛的能力建设活动将侧重于培养早期职业研究人员和同行研究人员。有严重精神疾病实际经历的人和政策制定者是研究团队的重要组成部分。通过与多部门社区咨询小组密切合作来支持社区参与。

结论

HOPE将提供证据,以支持采取行动满足非洲不同环境下无家可归且患有严重精神疾病人群的需求和偏好。我们正在建立一个由研究人员、政策制定者、社区成员以及有严重精神疾病和无家可归实际经历的人组成的新伙伴关系,以推动由非洲主导的解决方案。主要成果将包括与背景相关的实践和政策指导,以支持实现包容性发展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b820/12037345/3b54846bdb9a/S2045796025000186_fig1.jpg

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