Alam Mohammad Khursheed, Hajeer Mohammad Younis, Abdulrahim M Alfaleh Muhanna, Ayman Falah Z Alfaleh, Abdulkarim F Alanazi Abdulmohsen
Department of Preventive Dentistry, College of Dentistry, Jouf University, Sakaka 72345, Saudi Arabia.
Department of Dental Research Cell, Saveetha Institute of Medical and Technical Sciences, Saveetha Dental College and Hospitals, Chennai 600077, India.
Bioinformation. 2025 Jan 31;21(1):62-65. doi: 10.6026/973206300210062. eCollection 2025.
The change in oral microbiome diversity and composition during fixed orthodontic treatment was done using 16S rRNA sequencing. Saliva and plaque samples from 60 participants were analyzed at baseline, 3 months and 6 months. Alpha diversity significantly decreased at 3 months (mean: 2.8 ± 0.4) but partially recovered by 6 months (mean: 3.0 ± 0.3). Beta diversity analysis revealed significant microbial composition shifts (p < 0.01) with an increase in and a decline in Streptococcus sanguinis. Hence, orthodontic treatment alters the oral microbiome, emphasizing the need for enhanced oral hygiene to prevent dysbiosis.
利用16S rRNA测序技术对固定正畸治疗期间口腔微生物群的多样性和组成变化进行了研究。对60名参与者的唾液和牙菌斑样本在基线、3个月和6个月时进行了分析。3个月时α多样性显著降低（平均值：2.8±0.4），但6个月时部分恢复（平均值：3.0±0.3）。β多样性分析显示微生物组成发生了显著变化（p<0.01），其中 增加，血链球菌减少。因此，正畸治疗会改变口腔微生物群，强调需要加强口腔卫生以预防生态失调。
