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对比个体特异性复原力和补偿个性化框架:以反刍思维为例。

Contrasting Individual-Specific Resilience and Compensation Personalization Frameworks: The Case of Rumination.

作者信息

Zilcha-Mano Sigal

机构信息

School of Psychological Science, University of Haifa, Haifa, Israel.

出版信息

Biol Psychiatry Glob Open Sci. 2025 Mar 3;5(3):100478. doi: 10.1016/j.bpsgos.2025.100478. eCollection 2025 May.

Abstract

BACKGROUND

Rumination has been identified as a potential mechanism of therapeutic change, particularly in directive and focused psychotherapies for depression. Previous research has predominantly focused on either trait-like individual differences or state-like changes in rumination without integrating these aspects. In the current study, we propose a computational approach to investigating whether rumination serves as a compensatory or a resilience mechanism by integrating trait-like and state-like effects.

METHODS

Rumination and depressive symptoms were assessed (in  = 100) pretreatment and repeatedly throughout treatment. Mixed-level models were used to examine whether pretreatment trait-like rumination interacted with a time-variant variable of in-treatment state-like changes in rumination to predict subsequent changes in treatment outcomes. These models were used to determine whether individuals with higher or lower pretreatment trait-like levels of rumination benefited more from state-like reductions in rumination, thus contrasting the compensatory and resilience theoretical frameworks.

RESULTS

As hypothesized, the findings supported the compensatory framework; individuals with higher pretreatment trait-like levels of rumination benefited most from greater state-like reductions in rumination during treatment, as evidenced by greater subsequent symptom reduction ( = .04).

CONCLUSIONS

The findings refine our understanding of rumination as an individual-specific mechanism of therapeutic change, dependent on an individual's trait-like levels of rumination. The proposed computational approach enabled an empirical comparison of the 2 main theoretical frameworks of treatment personalization, compensatory and resilience, offering new insights into mechanisms that drive therapeutic change. Future studies could leverage the paradigm proposed here to examine for which patients and in what contexts mechanisms of change function as compensatory versus resilience mechanisms.

摘要

背景

反刍已被确定为治疗改变的一种潜在机制,尤其是在针对抑郁症的指导性和聚焦性心理治疗中。以往的研究主要集中在反刍的特质样个体差异或状态样变化上,而没有将这些方面整合起来。在本研究中,我们提出一种计算方法,通过整合特质样和状态样效应来研究反刍是作为一种补偿机制还是恢复力机制。

方法

在治疗前及整个治疗过程中反复评估100名患者的反刍和抑郁症状。使用混合水平模型来检验治疗前的特质样反刍是否与治疗中反刍的状态样变化这一时变变量相互作用,以预测治疗结果的后续变化。这些模型用于确定治疗前特质样反刍水平较高或较低的个体是否从反刍的状态样降低中获益更多,从而对比补偿和恢复力理论框架。

结果

正如假设的那样,研究结果支持补偿框架;治疗前特质样反刍水平较高的个体从治疗期间反刍的更大程度的状态样降低中获益最大,随后症状减轻更明显(p = 0.04)证明了这一点。

结论

这些发现完善了我们对反刍作为一种个体特异性治疗改变机制的理解,这种机制取决于个体的特质样反刍水平。所提出的计算方法能够对治疗个性化的两个主要理论框架——补偿和恢复力进行实证比较,为驱动治疗改变的机制提供了新的见解。未来的研究可以利用这里提出的范式来研究对于哪些患者以及在何种背景下改变机制作为补偿机制与恢复力机制发挥作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40f4/12008690/6d31abf0b2f6/gr1.jpg

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