Ultrasound detection of nonalcoholic steatohepatitis using convolutional neural networks with dual-branch global-local feature fusion architecture.

Nonalcoholic steatohepatitis (NASH) is a contributing factor to liver cancer, with ultrasound B-mode imaging as the first-line diagnostic tool. This study applied deep learning to ultrasound B-scan images for NASH detection and introduced an ultrasound-specific data augmentation (USDA) technique with a dual-branch global-local feature fusion architecture (DG-LFFA) to improve model performance and adaptability across imaging conditions. A total of 137 participants were included. Ultrasound images underwent data augmentation (rotation and USDA) for training and testing convolutional neural networks-AlexNet, Inception V3, VGG16, VGG19, ResNet50, and DenseNet201. Gradient-weighted class activation mapping (Grad-CAM) analyzed model attention patterns, guiding the selection of the optimal backbone for DG-LFFA implementation. The models achieved testing accuracies of 0.81-0.83 with rotation-based data augmentation. Grad-CAM analysis showed that ResNet50 and DenseNet201 exhibited stronger liver attention. When USDA simulated datasets from different imaging conditions, DG-LFFA (based on ResNet50 and DenseNet201) improved accuracy (0.79 to 0.84 and 0.78 to 0.83), recall (0.72 to 0.81 and 0.70 to 0.78), and F1 score (0.80 to 0.84 for both models). In conclusion, deep architectures (ResNet50 and DenseNet201) enable focused analysis of liver regions for NASH detection. Under USDA-simulated imaging variations, the proposed DG-LFFA framework further improves diagnostic performance.