Cavdar Vahit Can, Izgi Yagmur, Akbas Feray
University of Health Sciences, Department of Internal Medicine, Istanbul Training and Research Hospital, Istanbul, Turkey.
Hormones (Athens). 2025 Apr 22. doi: 10.1007/s42000-025-00657-z.
Obesity has been linked to an elevated susceptibility to development of erectile dysfunction, yet the interplay between sex hormone levels, sexual function, and obesity remains unclear. This study aimed to investigate sexual dysfunction among male patients with obesity and to emphasize the importance of recognizing the problem and pursuing solutions.
A total of 60 patients were included in the study (30 patients from the obesity center and 30 patients without obesity as the control group). Assessment of androgen hormone deficiency and erectile dysfunction was conducted through the implementation of AMS and IIEF-5 tests. The questionnaire includes aspects of medical history, demographic features, and lifestyle factors. Comprehensive measurements included BMI, WC, BP, lipid panel, total/free testosterone, sex-hormone-binding-globulin (SHBG), dehydroepiandrosterone-sulfate (DHEAS), fasting blood glucose (FBG), fasting insulin, and HbA1C levels. Results were evaluated using SPSS.
The AMS score in the obesity group was significantly lower compared to the group without obesity. The IIEF-5 score did not exhibit a statistically significant difference between the groups. Testosterone, free testosterone, SHBG, and HDL values were lower in the obesity group compared to the group without obesity.
Although conducted in a small sample, our findings strongly indicate a positive correlation between obesity and the risk of moderate to severe ED. Most of the time, this condition goes unarticulated, thereby adversely affecting the quality of life for individuals with obesity. Clinicians should pay more attention to patients experiencing sexual dysfunction, especially those with obesity.
肥胖与勃起功能障碍发生易感性升高有关，但性激素水平、性功能和肥胖之间的相互作用仍不清楚。本研究旨在调查肥胖男性患者的性功能障碍，并强调认识该问题及寻求解决方案的重要性。
本研究共纳入60例患者（30例来自肥胖中心，30例非肥胖患者作为对照组）。通过进行雄激素缺乏症评估量表（AMS）和国际勃起功能指数-5（IIEF-5）测试来评估雄激素缺乏和勃起功能障碍。问卷包括病史、人口统计学特征和生活方式因素等方面。综合测量包括体重指数（BMI）、腰围（WC）、血压（BP）、血脂谱、总睾酮/游离睾酮、性激素结合球蛋白（SHBG）、硫酸脱氢表雄酮（DHEAS）、空腹血糖（FBG）、空腹胰岛素和糖化血红蛋白（HbA1C）水平。使用社会科学统计软件包（SPSS）对结果进行评估。
肥胖组的AMS评分显著低于非肥胖组。两组间IIEF-5评分无统计学显著差异。肥胖组的睾酮、游离睾酮、SHBG和高密度脂蛋白（HDL）值低于非肥胖组。
尽管本研究样本量较小，但我们的研究结果强烈表明肥胖与中度至重度勃起功能障碍风险之间存在正相关。大多数情况下，这种情况未得到明确诊断，从而对肥胖个体的生活质量产生不利影响。临床医生应更加关注性功能障碍患者，尤其是肥胖患者。
