Sharma Ruchi, Sihag Naveen, Gupta Poorvi, Manna Kuntal, Yadav M Ramu
Department of Chemistry, Indian Institute of Technology Delhi, MS 720, 6th floor, Hauz Khas, New Delhi, 110016, India.
Chem Commun (Camb). 2025 May 13;61(40):7273-7276. doi: 10.1039/d5cc01034a.
A photoexcited nickel-catalyzed carbohalogenation reaction of fluoroalkenes has been demonstrated to afford halofluoroalkyl oxindoles featuring a quaternary center. The broad substrate scope with retention of fluorine atoms, followed by efficient synthetic transformations of iodo--difluoroalkyl oxindoles, highlights the advantages of this methodology. Additionally, control experiments and DFT calculations have been conducted to elucidate the significance of the triplet-excited state of the nickel catalyst.
已证明光激发镍催化的氟代烯烃碳卤化反应可得到具有季碳中心的卤代氟烷基羟吲哚。该反应具有广泛的底物范围且能保留氟原子，随后碘代二氟烷基羟吲哚的高效合成转化突出了这种方法的优势。此外，还进行了对照实验和密度泛函理论计算，以阐明镍催化剂三线态激发态的重要性。
