盘基网柄菌中自诱导的制霉菌素抗性
Self-induced nystatin resistance in Dictyostelium discoideum.
作者信息
Kasbekar D P, Madigan S, Katz E R
出版信息
Antimicrob Agents Chemother. 1985 Jun;27(6):974-6. doi: 10.1128/AAC.27.6.974.
Abstract
The cellular slime mold Dictyostelium discoideum is normally susceptible to the action of the polyene antibiotic nystatin. We describe conditions under which transient nystatin resistance can be induced in the absence of detectable changes in sterol composition. These results suggest that nystatin plays a positive role in promoting resistance to itself.
摘要
细胞黏菌盘基网柄菌通常对多烯抗生素制霉菌素敏感。我们描述了在甾醇组成未检测到变化的情况下诱导短暂制霉菌素抗性的条件。这些结果表明制霉菌素在促进自身抗性方面发挥了积极作用。
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