Kvernberg Joachim, Henriksen Finn Lund, Lauridsen Kasper Glerup, Rehn Marius, Hansen Peter Martin
Department of Cardiology, Odense University Hospital, Odense, Denmark.
Aarhus University Hospital, Aarhus, Denmark.
Acta Anaesthesiol Scand. 2025 May;69(5):e70041. doi: 10.1111/aas.70041.
During air travel, the decrease in air pressure leads to a decrease in oxygen partial pressure causing oxygen desaturation. Every year, several commercial aircraft need to divert and perform unscheduled landings due to hypoxic symptoms or medical emergencies. How individuals are affected depends on their physical and medical conditions, as well as the cabin pressure of the aircraft. The phenomenon is of particular concern for individuals with pre-existing medical conditions, as it may lead to hypoxic symptoms and necessitate unscheduled landings in some cases. The investigators aim to investigate the existing literature to explore how the impact of reduced oxygen partial pressure affects the oxygen saturation as a result of a decrease in cabin pressure due to aircraft altitude, and to assess the frequency of hypoxic symptoms reported during air travel. The purpose of the scoping review is to investigate the relationship between altitude, cabin pressure, and patient oxygenation during air travel. Further, the investigators will report the frequency of the reporting of hypoxic symptoms in the studies conducted.
This scoping review will be conducted in accordance with the Cochrane Handbook and Joanna Briggs Institute Manual for Scoping Reviews. The review question will be formulated using the Population, Intervention, Comparator, Outcome, Study Design, Timeframe (PICOST) framework. Every study design is eligible, apart from reviews, meta-analyses, comments/letters without original data, case reports with less than five cases, animal studies, and in vitro studies. The investigators will include all articles in English or Scandinavian. The investigators will base their conclusions on the findings of the review.
According to Danish law, scoping reviews are exempt from ethics committee approval. The investigators will publish results from the scoping review in a peer-reviewed journal and present the results at scientific conferences.
在航空旅行期间，气压降低导致氧分压下降，从而引起氧饱和度降低。每年，有几架商业飞机因缺氧症状或医疗紧急情况需要改道并进行非计划降落。个体受影响的程度取决于其身体和健康状况以及飞机客舱压力。对于已有健康问题的个体而言，这一现象尤其值得关注，因为在某些情况下它可能导致缺氧症状并需要非计划降落。研究人员旨在调查现有文献，以探讨由于飞机高度导致客舱压力降低，氧分压降低的影响如何作用于氧饱和度，并评估航空旅行期间报告的缺氧症状的频率。本综述的目的是研究航空旅行期间高度、客舱压力与患者氧合之间的关系。此外，研究人员将报告所开展研究中缺氧症状的报告频率。
本综述将按照Cochrane手册和乔安娜·布里格斯研究所综述手册进行。综述问题将使用人群、干预措施、对照、结局、研究设计、时间框架（PICOST）框架来制定。除综述、荟萃分析、无原始数据的评论/信函、病例数少于5例的病例报告、动物研究和体外研究外，所有研究设计均符合条件。研究人员将纳入所有英文或斯堪的纳维亚语文章。研究人员将根据综述结果得出结论。
根据丹麦法律，综述无需伦理委员会批准。研究人员将在同行评审期刊上发表综述结果，并在科学会议上展示结果。
